Fight disease at the level of DNA: infection, cancer, and gene therapy.

CareersGenetic CounselorImmunologistOncologistBiotech Researcher

PLTW-GENDPLTW Biomedical Science

The Genetics of Disease

How a single change in 3 billion letters of DNA can change a life.

Ohio WebXam: Genetics of Disease · 072130PLTW: Medical Interventions (MI)

Open Clever, then myPLTW How to get there: open Clever and sign in with your Microsoft (district) account. Both myPLTW and Schoology are in Clever. Do the activity in myPLTW. Turn the work in on this site or hand it to Mr. Mendoza, because that is the step that counts as submitted. Schoology only shows your report-card grade later.

Active Study: flashcards, decks & how-toStudy GenD cards in your browser, download the Anki deck, and learn the NotebookLM + Anki workflow.

Learning Centers: get unstuck at your levelMissing a step? Start below your level. Ready for more? Go past it. Every skill has worked practice, short videos, and the jobs that use it.

GenD: weeks of instruction before the WebXam

0 of 17 instructional weeks done17 left before WebXam

My checks & progress- take your exit tickets and see your growth

What the WebXam tests (072130)

Your end-of-course Ohio test, Genetics of Disease, is a 40-question exam. Here is the published item-bank weighting for the domains on that test.

Bio-Molecular Technology

56.18%

Culturing

20.22%

Laboratory Standard Operational Procedures

12.36%

Biotechnology Research and Experiments

11.24%

Weights are the canonical published WebXam item-bank blueprint (the PDF). WebXam's live blueprint page shows different numbers for some courses; the PDF is the citable source of record. The passing score is set by the state per test form and is not published here.

Where work goes

Which folder does each piece go to?

77 class days, folders and at-home chips

The story

What will this actually feel like?

17 weeks, a student's voice

Official PLTW Medical Interventions Course Outline

Medical Interventions is the course we teach. Your Ohio test has a different name: Genetics of Disease (072130).

Open

Week-by-week overview

Conference reflection & progress Days off & why

Semester 1 (Fall)

Single-semester Genetics of Disease (Medical Interventions): the full in-class curriculum, then the WebXam window. Every unit is taught in class; nothing is pushed to extra credit.

WeekDatesFocusDue by week end

Aug 24–28

Orientation: daily icebreakers, the daily lesson pages and website, what notes should look like (Cornell + the 6 Rs), the lab notebook, lab safety, the PLTW web portal, and a Friday WebXam pretest.This week

Aug 24–28

procedureroutinePPESDS

Orientation checklist, signed safety contract, notebook sample, and baseline WebXam pretest complete.

Aug 31–Sep 1

Course launch, safety, Smith family case, intervention categories, and the daily submission routine.

Aug 31–Sep 1

interventiondiagnosisprognosisevidence

Safety contract, notebook setup, intervention inventory.

Sep 2–9

Outbreak investigation, symptom clusters, pathogen categories, evidence maps. Monday debate: isolation vs. autonomy.

Sep 2–9

pathogensymptomsignoutbreak

Outbreak relationship map and CER diagnosis hypothesis.

Sep 10–14

DNA identification, sequencing, BLAST, controls, query coverage, and E-value.

Sep 10–14

DNA sequencePCRSanger sequencingBLAST

Pathogen ID mini-report.

Sep 15–18

Concentration, serial dilution, standard curves, antigen–antibody binding, direct vs. indirect ELISA.

Sep 15–18

antigenantibodyELISAserial dilution

ELISA pre-lab quiz and dilution table.

Sep 21–24

Reading qualitative vs. quantitative color results; false positive/negative risk; control logic.

Sep 21–24

positive controlnegative controlspecificitysensitivity

ELISA lab report with controls, diagnosis, limitations.

Sep 25–29

Bacterial structure, antibiotic mechanisms, MIC, resistance, and stewardship.

Sep 25–29

antibioticbacteriostaticbactericidalMIC

Antibiotic choice CER quiz.

Sep 30–Oct 2

Aseptic technique, culturing, selection, resistance genes, and data reliability.

Sep 30–Oct 2

aseptic techniqueculturecolonyinhibition

Superbug lab data table or image-analysis packet.

Oct 5–8

Auditory anatomy, audiograms, cochlear implants, immune response, vaccine design, herd immunity.

Oct 5–8

cochleahair cellaudiogramvaccine

Hearing / vaccine intervention case recommendation.

Oct 12–15

Inheritance review, pedigree logic, SNPs, genetic counseling, and the MP1 data inflection.

Oct 12–15

allelegenotypephenotypepedigree

Genetic counseling case memo and tracker audit.

Oct 16–20

PCR, restriction enzymes, electrophoresis, microarrays, and the limits of each method.

Oct 16–20

primerrestriction enzymegel electrophoresismicroarray

Genetic testing methods quiz.

Oct 26–29

Gene therapy, viral vectors, somatic vs. germline editing, CRISPR basics, reproductive screening.

Oct 26–29

gene therapyvectorCRISPR-Cas9somatic

Gene therapy ethics CER.

Oct 30–Nov 5

Molecule-to-patient decision making; validity, reliability, false results, and treatment planning.

Oct 30–Nov 5

molecular diagnosisvalidityreliabilityfalse positive

Unit 2 summative test and PLTW tracker audit.

Nov 6–9

Cancer as loss of regulation; tumor types; diagnostic workflow.

Nov 6–9

cancertumorbenignmalignant

Short-week cancer launch checkpoint.

Oct 21–23

Differential expression, fold change, correlation, disease risk vs. diagnosis.

Oct 21–23

gene expressionmRNAupregulateddownregulated

Microarray analysis report.

Nov 10–17

Biopsy, imaging, staging, chemo, radiation, targeted therapy, response, side effects.

Nov 10–17

biopsystagingchemotherapyradiation

Cancer treatment recommendation memo.

Nov 23–30

Plasmids, restriction enzymes, ligase, transformation, protein expression.

Nov 23–30

plasmidrecombinant DNAligasetransformation

Cloning workflow quiz.

Dec 1–4

GFP, chromatography, SDS-PAGE / gel interpretation, purity and QC.

Dec 1–4

GFPchromatographyelutionprotein marker

Protein purification lab report.

WebXam

Jan 4–8

WebXam testing block

Jan 4–8

WebXam testing progress confirmed.

WebXam

Jan 11–15

WebXam testing block

Jan 11–15

WebXam testing progress confirmed.

Tip: click any week to open its overview, daily lesson links, vocabulary, resources, WebXam practice, and PLTW direction. Semester 2 repeats the same learning arc on new dates.

Daily plan: every class day

One page per instructional day, on the real calendar. Open today's date for the target, agenda, PLTW work, what is due, guided notes, and what to do if you were absent.

★ Want extra credit? This track opens after Unit 2.★ 072130 Molecular Lab Review: optional extra-credit project (solo or group)An optional review that pulls the highest-weight exam lab skills together for extra practice. Solo or group, for extra credit.Opens after the cardiovascular unit, due by the WebXam review. about 1.5 to 2 hours total, at your own pace before the exam.

Open any daily lessonDaily calendar

Fall (Semester 1)

Wk 1

Mon 08/24 · Welcome, expectations, and how this class works Tue 08/25 · How to use the class website Wed 08/26 · Cornell notes and the 6 Rs Thu 08/27 · Lab safety, myPLTW, and how to submit Fri 08/28 · WebXam pretest and goal setting

Wk 2

Mon 08/31 · Lab safety and SDS practical Tue 09/01 · Lab notebook and portfolio Wed 09/02 · Bioethics debate: isolation vs autonomy Thu 09/03 · Signs vs symptoms Fri 09/04 · Pathogen categories

Wk 3

Tue 09/08 · Outbreak relationship map Wed 09/09 · Outbreak CER submission Thu 09/10 · BLAST computer lab Fri 09/11 · E-value and query coverage

Wk 4

Mon 09/14 · Pathogen-ID report submission Tue 09/15 · Bioethics debate: who gets the test Wed 09/16 · Concentration and serial dilution Thu 09/17 · Antigen-antibody and ELISA model Fri 09/18 · Dilution and ELISA model submission

Wk 5

Mon 09/21 · Bioethics debate: false results Tue 09/22 · Wet ELISA lab Wed 09/23 · Specificity vs sensitivity Thu 09/24 · ELISA lab report submission Fri 09/25 · Bioethics debate: antibiotic stewardship

Wk 6

Mon 09/28 · Disk diffusion and MIC lab Tue 09/29 · Antibiotics report submission Wed 09/30 · Bioethics debate: research vs risk Thu 10/01 · Culturing and colony data lab Fri 10/02 · Mutation, HGT, and superbugs

Wk 7

Mon 10/05 · Cochlear implant debate Tue 10/06 · Audiogram interpretation Wed 10/07 · Vaccine and disease-model lab Thu 10/08 · Herd immunity math

Wk 8

Mon 10/12 · Genetic privacy debate Tue 10/13 · Pedigree logic Wed 10/14 · SNP and PTC case Thu 10/15 · Genetic counseling memo Fri 10/16 · Access-to-results debate

Wk 9

Mon 10/19 · Gel electrophoresis lab Tue 10/20 · Microarray introduction Wed 10/21 · Expression data lab Thu 10/22 · Heat-map claim Fri 10/23 · Microarray report submit

Wk 10

Mon 10/26 · Germline editing debate Tue 10/27 · Viral vector chart Wed 10/28 · CRISPR and reproductive screening Thu 10/29 · Gene therapy ethics CER Fri 10/30 · Screening equity debate

Wk 11

Wed 11/04 · Evidence sort and false results Thu 11/05 · Treatment recommendation draft Fri 11/06 · Cancer screening debate

Wk 12

Mon 11/09 · Microscopy image baseline Tue 11/10 · Trial-access debate Thu 11/12 · Biopsy and staging Fri 11/13 · Chemo and radiation

Wk 13

Mon 11/16 · Targeted therapy Tue 11/17 · Treatment recommendation memo Wed 11/18 · Organ-allocation debate Thu 11/19 · Protocol and data stations Fri 11/20 · Tissue-engineering comparison

Wk 14

Mon 11/23 · Engineered-protein debate Tue 11/24 · Cloning and purification workflow

Wk 15

Mon 11/30 · Protein expression Tue 12/01 · Purification overview Wed 12/02 · Protein-purification lab Thu 12/03 · SDS-PAGE gel results Fri 12/04 · Protein purification lab report

Wk 16

Mon 12/07 · Allocation debate Tue 12/08 · Dialysis and matching simulation Wed 12/09 · Compatibility and rejection Thu 12/10 · Allocation CER Fri 12/11 · Emerging-tech debate

Wk 17

Mon 12/14 · Xenotransplantation and bionics Tue 12/15 · Design analysis Wed 12/16 · Design critique Thu 12/17 · Final-ethics debate Fri 12/18 · Integrated case checkpoint

GenD calendar

Submission Zone

Drop your GenD project in the OneDrive folder, or hand it to Mr. Mendoza in class. Both count. Sign in with your Microsoft (district) account, not a personal one. Nothing is turned in on Schoology: that is where the report-card grade shows up later.

Name the file exactly like this, with two underscores between the name and the title:

Lastname_Firstname__Assignment Title.pdf

Two underscores between the name and the title. Do not put your student ID in the file name: your district sign-in already tells me it is you. A file named any other way is not lost. It waits in a review folder until it is sorted by hand, so it is graded later.

Your receipt. Your own upload panel says Uploaded, with a green check beside the file name. That is your receipt. Screenshot it if you want a record of your own. Do not wait for the file to appear in a list. You should not be able to see anyone else's work in there. If you can see other students' files, stop and tell Mr. Mendoza.

Open the OneDrive drop

What you'll learn

Construct and interpret a pedigree to predict inheritance

Explain how common genetic tests detect disease risk

Weigh ethical considerations of genetic screening

Open the daily plan above. Every class day lists what you will learn, the lab, the new words, and WebXam practice.

Was this helpful?

Give quick feedback Ask a question Family feedback