John Hay
John Hay Biomedical
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Fight disease at the level of DNA — infection, cancer, and gene therapy.

CareersGenetic CounselorImmunologistOncologistBiotech Researcher
PLTW-GENDPLTW Biomedical Science

The Genetics of Disease

How a single change in 3 billion letters of DNA can change a life.

Ohio WebXam: Genetics of Disease · 072130PLTW: Medical Interventions (MI)
My Class
Submit on Schoology How to get there: open the CMSD website, click Clever, sign in with your Microsoft (district) account, then open Schoology from Clever.
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What the WebXam tests (072130)

Your end-of-course Ohio test, Genetics of Disease, is a 40-question exam. Here is the published item-bank weighting for the domains on that test.

Bio-Molecular Technology
56.18%
Culturing
20.22%
Laboratory Standard Operational Procedures
12.36%
Biotechnology Research and Experiments
11.24%

Weights are the published WebXam item-bank blueprint. The passing score is set by the state per test form and is not published here.

Official PLTW Medical Interventions Course Outline

Medical Interventions is the delivery curriculum; the exam is Ohio Genetics of Disease (072130).

Open

Week-by-week overview

Conference reflection & progressDays off & why

Semester 1 (Fall)

Single-semester Genetics of Disease (Medical Interventions): full in-class curriculum, then the WebXam window. Lowest-WebXam-value units move to the optional extra-credit track.

1
Course launch, safety, Smith family case, intervention categories, and the daily submission routine.
Aug 24–27
2
Outbreak investigation, symptom clusters, pathogen categories, evidence maps. Monday debate: isolation vs. autonomy.
Aug 28–Sep 3
3
DNA identification, sequencing, BLAST, controls, query coverage, and E-value.
Sep 4–10
4
Concentration, serial dilution, standard curves, antigen–antibody binding, direct vs. indirect ELISA.
Sep 11–17
5
Reading qualitative vs. quantitative color results; false positive/negative risk; control logic.
Sep 18–23
6
Bacterial structure, antibiotic mechanisms, MIC, resistance, and stewardship.
Sep 24–30
7
Aseptic technique, culturing, selection, resistance genes, and data reliability.
Oct 1–6
8
Auditory anatomy, audiograms, cochlear implants, immune response, vaccine design, herd immunity.
Oct 7–12
9
Inheritance review, pedigree logic, SNPs, genetic counseling, and the MP1 data inflection.
Oct 13–19
10
PCR, restriction enzymes, electrophoresis, microarrays, and the limits of each method.
Oct 20–26
11
Differential expression, fold change, correlation, disease risk vs. diagnosis.
Oct 27–29
12
Gene therapy, viral vectors, somatic vs. germline editing, CRISPR basics, reproductive screening.
Oct 30–Nov 6
13
Molecule-to-patient decision making; validity, reliability, false results, and treatment planning.
Nov 9–10
14
Cancer as loss of regulation; tumor types; diagnostic workflow.
Nov 12–13
15
Biopsy, imaging, staging, chemo, radiation, targeted therapy, response, side effects.
Nov 16–18
16
Plasmids, restriction enzymes, ligase, transformation, protein expression.
Nov 19–30
17
GFP, chromatography, SDS-PAGE / gel interpretation, purity and QC.
Dec 1–4
WX1
WebXam testing block
Jan 4–8
WX2
WebXam testing block
Jan 11–15

Semester 2 (Spring)

Single-semester Genetics of Disease (Medical Interventions): full in-class curriculum, then the WebXam window. Lowest-WebXam-value units move to the optional extra-credit track.

1
Course launch, safety, Smith family case, intervention categories, and the daily submission routine.
Jan 19–22
2
Outbreak investigation, symptom clusters, pathogen categories, evidence maps. Monday debate: isolation vs. autonomy.
Jan 25–29
3
DNA identification, sequencing, BLAST, controls, query coverage, and E-value.
Feb 1–4
4
Concentration, serial dilution, standard curves, antigen–antibody binding, direct vs. indirect ELISA.
Feb 5–11
5
Reading qualitative vs. quantitative color results; false positive/negative risk; control logic.
Feb 16–19
6
Bacterial structure, antibiotic mechanisms, MIC, resistance, and stewardship.
Feb 22–26
7
Aseptic technique, culturing, selection, resistance genes, and data reliability.
Mar 1–4
8
Auditory anatomy, audiograms, cochlear implants, immune response, vaccine design, herd immunity.
Mar 5–9
9
Inheritance review, pedigree logic, SNPs, genetic counseling, and the MP1 data inflection.
Mar 10–16
10
PCR, restriction enzymes, electrophoresis, microarrays, and the limits of each method.
Mar 17–23
11
Differential expression, fold change, correlation, disease risk vs. diagnosis.
Mar 24–Apr 5
12
Gene therapy, viral vectors, somatic vs. germline editing, CRISPR basics, reproductive screening.
Apr 6–9
13
Molecule-to-patient decision making; validity, reliability, false results, and treatment planning.
Apr 12–13
14
Cancer as loss of regulation; tumor types; diagnostic workflow.
Apr 14–15
15
Biopsy, imaging, staging, chemo, radiation, targeted therapy, response, side effects.
Apr 16–20
16
Plasmids, restriction enzymes, ligase, transformation, protein expression.
Apr 21–27
17
GFP, chromatography, SDS-PAGE / gel interpretation, purity and QC.
Apr 28–May 3
WX1
WebXam testing block
May 17–21
WX2
WebXam testing block
May 24–28

Tip: click any week to open its overview, daily lesson links, vocabulary, resources, WebXam practice, and PLTW direction. Semester 2 repeats the same learning arc on new dates.

Daily plan — every class day

One page per instructional day, on the real calendar. Open today's date for the target, agenda, PLTW work, what is due, guided notes, and what to do if you were absent.

★ Optional extra-credit track (opens after Unit 2)
Open any daily lessonDaily calendar
Fall (Semester 1)
Wk 1
Mon 08/24 · Lab safety and SDS practicalTue 08/25 · Lab notebook and portfolioWed 08/26 · Intervention inventoryThu 08/27 · Launch portfolio submissionFri 08/28 · Bioethics debate: isolation vs autonomy
Wk 2
Mon 08/31 · Signs vs symptomsTue 09/01 · Pathogen categoriesWed 09/02 · Outbreak relationship mapThu 09/03 · Outbreak CER submissionFri 09/04 · DNA sequencing basics
Wk 3
Tue 09/08 · BLAST computer labWed 09/09 · E-value and query coverageThu 09/10 · Pathogen-ID report submissionFri 09/11 · Bioethics debate: who gets the test
Wk 4
Mon 09/14 · Concentration and serial dilutionTue 09/15 · Standard curve and lab prepWed 09/16 · Antigen-antibody and ELISA modelThu 09/17 · Dilution and ELISA model submissionFri 09/18 · Bioethics debate: false results
Wk 5
Mon 09/21 · Controls and wet-lab planTue 09/22 · Wet ELISA labWed 09/23 · Specificity vs sensitivityThu 09/24 · Bioethics debate: antibiotic stewardshipFri 09/25 · Antibiotic mechanisms
Wk 6
Mon 09/28 · Disk diffusion and MIC labTue 09/29 · Resistance and stewardshipWed 09/30 · Antibiotics report submissionThu 10/01 · Bioethics debate: research vs riskFri 10/02 · Aseptic technique
Wk 7
Mon 10/05 · Culturing and colony data labTue 10/06 · Mutation, HGT, and superbugsWed 10/07 · Cochlear implant debateThu 10/08 · Audiogram interpretation
Wk 8
Mon 10/12 · Vaccine and disease-model labTue 10/13 · Genetic privacy debateWed 10/14 · Pedigree logicThu 10/15 · SNP and PTC caseFri 10/16 · Genetic counseling memo
Wk 9
Mon 10/19 · MP1 tracker auditTue 10/20 · Access-to-results debateWed 10/21 · PCR and primersThu 10/22 · Gel electrophoresis labFri 10/23 · Microarray introduction
Wk 10
Mon 10/26 · Methods quizTue 10/27 · Expression data labWed 10/28 · Heat-map claimThu 10/29 · Microarray report submitFri 10/30 · Germline editing debate
Wk 11
Wed 11/04 · Viral vector chartThu 11/05 · CRISPR and reproductive screeningFri 11/06 · Gene therapy ethics CER
Wk 12
Mon 11/09 · Screening equity debateTue 11/10 · Molecule-to-patient case packetThu 11/12 · Cancer screening debateFri 11/13 · Microscopy image baseline
Wk 13
Mon 11/16 · Trial-access debateTue 11/17 · Biopsy and stagingWed 11/18 · Chemo and radiationThu 11/19 · Engineered-protein debateFri 11/20 · Plasmids and enzymes
Wk 14
Mon 11/23 · Cloning and purification workflowTue 11/24 · Protein expression
Wk 15
Mon 11/30 · Cloning workflow quizTue 12/01 · Purification overviewWed 12/02 · GFP and chromatographyThu 12/03 · Protein-purification labFri 12/04 · SDS-PAGE gel results
Spring (Semester 2)
Wk 1
Tue 01/19 · Lab safety and SDS practicalWed 01/20 · Lab notebook and portfolioThu 01/21 · Intervention inventoryFri 01/22 · Launch portfolio submission
Wk 2
Mon 01/25 · Bioethics debate: isolation vs autonomyTue 01/26 · Signs vs symptomsWed 01/27 · Pathogen categoriesThu 01/28 · Outbreak relationship mapFri 01/29 · Outbreak CER submission
Wk 3
Mon 02/01 · DNA sequencing basicsTue 02/02 · BLAST computer labWed 02/03 · E-value and query coverageThu 02/04 · Pathogen-ID report submissionFri 02/05 · Bioethics debate: who gets the test
Wk 4
Mon 02/08 · Concentration and serial dilutionTue 02/09 · Standard curve and lab prepWed 02/10 · Antigen-antibody and ELISA modelThu 02/11 · Dilution and ELISA model submission
Wk 5
Tue 02/16 · Bioethics debate: false resultsWed 02/17 · Controls and wet-lab planThu 02/18 · Wet ELISA labFri 02/19 · Specificity vs sensitivity
Wk 6
Mon 02/22 · Bioethics debate: antibiotic stewardshipTue 02/23 · Antibiotic mechanismsWed 02/24 · Disk diffusion and MIC labThu 02/25 · Resistance and stewardshipFri 02/26 · Antibiotics report submission
Wk 7
Mon 03/01 · Bioethics debate: research vs riskTue 03/02 · Aseptic techniqueWed 03/03 · Culturing and colony data labThu 03/04 · Mutation, HGT, and superbugsFri 03/05 · Cochlear implant debate
Wk 8
Mon 03/08 · Audiogram interpretationTue 03/09 · Vaccine and disease-model labWed 03/10 · Genetic privacy debateThu 03/11 · Pedigree logicFri 03/12 · SNP and PTC case
Wk 9
Mon 03/15 · Genetic counseling memoTue 03/16 · MP1 tracker auditWed 03/17 · Access-to-results debateThu 03/18 · PCR and primersFri 03/19 · Gel electrophoresis lab
Wk 10
Mon 03/22 · Microarray introductionTue 03/23 · Methods quizWed 03/24 · Expression data labThu 03/25 · Heat-map claim
Wk 12
Mon 04/05 · Microarray report submitTue 04/06 · Germline editing debateWed 04/07 · Viral vector chartThu 04/08 · CRISPR and reproductive screeningFri 04/09 · Gene therapy ethics CER
Wk 13
Mon 04/12 · Screening equity debateTue 04/13 · Molecule-to-patient case packetWed 04/14 · Cancer screening debateThu 04/15 · Microscopy image baselineFri 04/16 · Trial-access debate
Wk 14
Mon 04/19 · Biopsy and stagingTue 04/20 · Chemo and radiationWed 04/21 · Engineered-protein debateThu 04/22 · Plasmids and enzymesFri 04/23 · Cloning and purification workflow
Wk 15
Mon 04/26 · Protein expressionTue 04/27 · Cloning workflow quizWed 04/28 · Purification overviewThu 04/29 · GFP and chromatographyFri 04/30 · Protein-purification lab
Wk 16
Mon 05/03 · SDS-PAGE gel results

GenD calendar

Submission Zone

Drop your GenD project here. Use a clear file name (your initials + project). Routine work still goes to Schoology (via the CMSD portal).

Upload a project

What you'll learn

Construct and interpret a pedigree to predict inheritance
Explain how common genetic tests detect disease risk
Weigh ethical considerations of genetic screening

Open the daily plan above for day-by-day targets, labs, vocabulary, and WebXam practice.

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