Fight disease at the level of DNA: infection, cancer, and gene therapy.

CareersGenetic CounselorImmunologistOncologistBiotech Researcher

PLTW-GENDPLTW Biomedical Science

The Genetics of Disease

How a single change in 3 billion letters of DNA can change a life.

Ohio WebXam: Genetics of Disease · 072130PLTW: Medical Interventions (MI)

MI worked exemplar library

My Class

Course Syllabus (Drive PDF) Family Guide (Drive PDF)

Open Clever, then myPLTW Sign in to Clever with your district Microsoft account to open Schoology or myPLTW. Follow today's posted steps. If myPLTW will not open, use the posted alternative and tell Mr. Mendoza. Turn in your completed work through the Schoology assignment.

Active Study: flashcards, decks & how-toStudy GenD cards in your browser, download the Anki deck, and learn the NotebookLM + Anki workflow.

Learning Centers: get unstuck at your levelMissing a step? Start below your level. Ready for more? Go past it. Every skill has worked practice, short videos, and the jobs that use it.

GenD: weeks of instruction before the WebXam

2 of 17 instructional weeks done15 left before WebXam

115 days until the WebXam window · Window opens Jan 4, 2027

My checks- take exit tickets and benchmarks

What the WebXam tests (072130)

Your end-of-course Ohio test, Genetics of Disease, is a 40-question exam. Here is the published item-bank weighting for the domains on that test.

Molecular and Genetic Technology

57.73%

Culturing

16.49%

Laboratory Standard Operational Procedures

14.43%

Biotechnology Research and Experiments

11.34%

Weights are WebXam's live item-bank blueprint. Where the older hosted PDF disagrees, the live blueprint is what WebXam scores against: the outcome reports WebXam returns to this school print the live percentages. The passing score is set by the state per test form and is not published here.

Where work goes

Which folder does each piece go to?

77 class days, folders and at-home chips

The story

What will this actually feel like?

17 weeks, a student's voice

Official PLTW Medical Interventions Course Outline

Medical Interventions is the course we teach. Your Ohio test has a different name: Genetics of Disease (072130).

Open

Week-by-week overview

Conference reflection & progress Friday reflection Days off & why

Semester 1 (Fall)

Single-semester Genetics of Disease (Medical Interventions): the full in-class curriculum, then the WebXam window. Some later units also carry an optional extra-credit track; see the reserve page for which ones.

WeekDatesFocusDue by week end

Aug 24–28

Orientation: daily icebreakers, the daily lesson pages and website, what notes should look like (Cornell + the 6 Rs), the lab notebook, lab safety, the PLTW web portal, and a Friday WebXam pretest.

Aug 24–28

procedureroutinePPESDS

Orientation checklist, signed safety contract, notebook sample, and baseline WebXam pretest complete.

Aug 31–Sep 4

Course launch, safety, Smith family case, intervention categories, and the daily submission routine.

Aug 31–Sep 4

interventiondiagnosisprognosisevidence

Safety contract, notebook setup, intervention inventory.

Sep 8–11

Outbreak investigation, symptom clusters, pathogen categories, evidence maps. Monday debate: isolation vs. autonomy.

Sep 8–11

pathogensymptomsignoutbreak

Outbreak relationship map and CER diagnosis hypothesis.

Sep 14–18

DNA identification, sequencing, BLAST, controls, query coverage, and E-value.This week

Sep 14–18

DNA sequencePCRSanger sequencingBLAST

Pathogen ID mini-report.

Sep 21–25

Concentration, serial dilution, standard curves, antigen–antibody binding, direct vs. indirect ELISA.

Sep 21–25

antigenantibodyELISAserial dilution

ELISA pre-lab quiz and dilution table.

Sep 28–Oct 2

Reading qualitative vs. quantitative color results; false positive/negative risk; control logic.

Sep 28–Oct 2

positive controlnegative controlspecificitysensitivity

ELISA lab report with controls, diagnosis, limitations.

Oct 5–8

Aseptic technique, culturing, selection, resistance genes, and data reliability.

Oct 5–8

aseptic techniqueculturecolonyinhibition

Superbug lab data table or image-analysis packet.

Oct 12–16

Auditory anatomy, audiograms, cochlear implants, immune response, vaccine design, herd immunity.

Oct 12–16

cochleahair cellaudiogramvaccine

Hearing / vaccine intervention case recommendation.

Oct 19–23

Inheritance review, pedigree logic, SNPs, genetic counseling, and the MP1 data inflection.

Oct 19–23

allelegenotypephenotypepedigree

Genetic counseling case memo and tracker audit.

Oct 26–30

PCR, restriction enzymes, electrophoresis, microarrays, and the limits of each method.

Oct 26–30

primerrestriction enzymegel electrophoresismicroarray

Genetic testing methods quiz.

Nov 4–6

Gene therapy, viral vectors, somatic vs. germline editing, CRISPR basics, reproductive screening.

Nov 4–6

gene therapyvectorCRISPR-Cas9somatic

Gene therapy ethics CER.

Nov 9–13

Molecule-to-patient decision making; validity, reliability, false results, and treatment planning.

Nov 9–13

molecular diagnosisvalidityreliabilityfalse positive

Unit 2 summative test and PLTW tracker audit.

Nov 16–20

Cancer as loss of regulation; tumor types; diagnostic workflow.

Nov 16–20

cancertumorbenignmalignant

Short-week cancer launch checkpoint.

Nov 23–24

Biopsy, imaging, staging, chemo, radiation, targeted therapy, response, side effects.

Nov 23–24

biopsystagingchemotherapyradiation

Cancer treatment recommendation memo.

Nov 30–Dec 4

Recombinant DNA, protein purification, dialysis / transplant matching, tissue engineering; final integrated closeout.

Nov 30–Dec 4

plasmidrecombinant DNApurificationdialysis

Complete MI curriculum portfolio. No new curriculum after Dec 11.

Dec 7–11

Plasmids, restriction enzymes, ligase, transformation, protein expression.

Dec 7–11

plasmidrecombinant DNAligasetransformation

Cloning workflow quiz.

Dec 14–18

Kidney function, dialysis, blood / HLA matching, rejection, allocation ethics.

Dec 14–18

nephrondialysisHLAcrossmatch

Organ allocation argument.

WebXam

Jan 4–8

WebXam testing block

Jan 4–8

WebXam testing progress confirmed.

WebXam

Jan 11–15

WebXam testing block

Jan 11–15

WebXam testing progress confirmed.

Tip: click any week to open its overview, daily lesson links, vocabulary, resources, WebXam practice, and PLTW direction. Semester 2 repeats the same learning arc on new dates.

Daily plan: every class day

One page per instructional day, on the real calendar. Open today's date for the target, agenda, PLTW work, what is due, guided notes, and what to do if you were absent.

★ Want extra credit? This track opens partway through the term.★ 072130 Molecular Lab Review: optional extra-credit project (solo or group)An optional review that pulls the highest-weight exam lab skills together for extra practice. Solo or group, for extra credit.Opens after the cardiovascular unit, due by the WebXam review. about 1.5 to 2 hours total, at your own pace before the exam.

Open any daily lessonDaily calendar

Fall (Semester 1)

Wk 1