Recombinant DNA, protein purification, dialysis / transplant matching, tissue engineering; final integrated closeout.
Your PLTW coursework: Medical Interventions ▸ Unit 4: How to Prevail When Organs Fail ▸ Lesson 4.1 Manufacturing Human Proteins / Lesson 4.3 Transplant / Lesson 4.4 Building a Better Body ▸ "Activity 4.1.3 Protein Purification", "Activity 4.3.1 Who Should Receive the Organ?", "Activity 4.3.2 Finding a Match", "Activity 4.4.1 Replacement Parts"
What to do if absent- CER:
- Claim, Evidence, Reasoning: make a claim, back it with evidence, explain your reasoning.
- SOP:
- Standard Operating Procedure, the exact steps to follow (especially in a lab).
- Tracker:
- Your PLTW progress log where you record completed evidence.
- myPLTW:
- The PLTW course site where you do the online activities. Find it in Clever with your Microsoft sign-in, right next to Schoology.
Map the Unit 4 path from recombinant DNA to transplant and assemble your Semester-1 final PLTW tracker evidence portfolio.
- 1Open the final tracker evidence packet in the PLTW course shell and skim the checklist before starting any station.
- 2Rotate through the protocol and data stations, recording one key term from each: , , , and scaffold.
- 3At the transplant station, note what HLA matching checks and why a close match lowers risk.
- 4List the four Unit 4 themes in order from molecule to patient and write a one-line link between each step.
- 5Audit your tracker evidence against the checklist and flag any missing item to finish this week.
- 6Draft one question for the Monday organ-allocation debate about how a limited supply of organs should be shared.
- • You'll be able to connect recombinant DNA, , , and transplant into one pathway.
- • You'll be able to explain why HLA matching matters for transplants.
- • You'll be able to audit your own portfolio against the tracker checklist.
Open any day for its full lesson, the work due that day, and guided notes.
Written final stance with one-sentence reason, plus a one-sentence rebuttal to the competing stakeholder.
Labeled recombinant-DNA flow diagram showing cutting, gene , host-cell , and a named product.
Three-station : fraction results, HLA scores, and scaffold comparison notes.
Your worksheet: the side you argued, your three strongest arguments, the opposing point you had to answer, and where you actually stand now.
Written final stance on engineered- access and pricing, plus a one-sentence rebuttal to the opposing strongest argument.
- Today matters because Unit 4 ties the whole semester together, from making a to saving a failing organ.
- Goal for today: walk the molecule-to-patient path and close out your Semester-1 final portfolio evidence.
- Monday's debate is organ allocation: with too few organs for everyone, how do we decide fairly who receives one?
- This is the Semester-1 final portfolio week, and every tracker item is graded in the PLTW course shell, so finalize it there.
Do this: Advance the Unit 4 overview benchmark by submitting your completed Semester-1 final tracker evidence portfolio on the class site.
- • Recombinant DNA joins a gene of interest into a so cells can make a useful .
- • filters blood when kidneys fail, and HLA matching compares immune markers before a transplant.
- • uses scaffolds to support new growth.
- • Map the Unit 4 pathway from recombinant DNA to transplant.
- • Audit a portfolio of tracker evidence against a checklist.
📋 Tracker evidence due this week: your complete Semester-1 final PLTW tracker portfolio submitted on the class site.
All PLTW activities are completed inside the PLTW course environment: this page only gives direction.
Use this chart to keep your place. Nothing on it is turned in through the portal.
| Day | Work | Turn in |
|---|---|---|
| Monday · Mon, Nov 30 | Organ-allocation debate | Written final stance with one-sentence reason, plus a one-sentence rebuttal to the competing stakeholder. |
| Tuesday · Tue, Dec 1 | Recombinant DNA flow | Labeled recombinant-DNA flow diagram showing plasmid cutting, gene insertion, host-cell transformation, and a named protein product. |
| Wednesday · Wed, Dec 2 | Protocol and data stations | Three-station data table: purification fraction results, HLA crossmatch scores, and scaffold comparison notes. |
| Thursday · Thu, Dec 3 | JCU bioethics 11: Genetic Defect Prevention and the Vargo request | Your worksheet: the side you argued, your three strongest arguments, the opposing point you had to answer, and where you actually stand now. |
| Friday · Fri, Dec 4 | Engineered-protein debate | Written final stance on engineered-protein access and pricing, plus a one-sentence rebuttal to the opposing strongest argument. |
- M: organ allocation debate
- T: recombinant DNA flow
- W: organ failure data
- Th: comparison
- F: final portfolio submit
Turn in: Recombinant DNA, protein purification, dialysis / transplant matching, tissue engineering; final integrated closeout. weekly work due Complete MI curriculum portfolio. No new curriculum after Dec 11.
Go to Schoology to turn this in.
Submit one PDF. Put your first and last name in the document header. Name the file: FirstName LastName - Assignment Title - YYYY-MM-DD.pdf.
Open Schoology PDF upload helpIf you cannot get in, see Mr. Mendoza. Do not skip the work.
4 panels from the illustrated semester.
Fiction. There is no such student. The lessons, labs and dates are the real planned course; the student, the classmates and the conversations are invented.
This explainer accompanies the PLTW lab protocol: watch it before lab.
Most days, this class is your PLTW coursework: and PLTW is online and individual. So being out usually just means doing exactly what we did in class, from home.
Open Clever, then myPLTWSign in to Clever with your district Microsoft account to open Schoology or myPLTW. Follow today's posted steps. If myPLTW will not open, use the posted alternative and tell Mr. Mendoza. Turn in your completed work through the Schoology assignment.
You can't do those from home: do this instead: Final PLTW tracker evidence packet.
Class still runs. A substitute will post today's plan: complete the online activity above; it's built to be self-guided. Need the concept taught without a teacher? Use this authoritative explainer:
MedlinePlus: Organ Transplantation
Classroom documents for this lesson are posted in Schoology. Open Clever, then Schoology, and find each one by the name shown on its card.
Use this for optional reserve or extra-credit work after the required class lesson is complete.
Placement rationale
Matched Organ failure overview and by path:Medical-Interventions/Unit-4_When-Organs-Fail/4.2_Organ-Failure; keywords:organ failure, kidney, dialysis. Score 146. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).
Use this for optional reserve or extra-credit work after the required class lesson is complete.
Placement rationale
Matched Organ failure overview and by path:Medical-Interventions/Unit-4_When-Organs-Fail/4.2_Organ-Failure; keywords:organ failure, kidney. Score 142. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).
Use this for optional reserve or extra-credit work after the required class lesson is complete.
Placement rationale
Matched Organ failure overview and by path:Medical-Interventions/Unit-4_When-Organs-Fail/4.2_Organ-Failure; keywords:kidney, renal. Score 138. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).
Sign in to Clever with your district Microsoft account to open Schoology or myPLTW. Follow today's posted steps. If myPLTW will not open, use the posted alternative and tell Mr. Mendoza. Turn in your completed work through the Schoology assignment.