All Learning Centers
Genetics of Disease (Medical Interventions): Learning Centers
52 centers · 5 units
Launch
Apply PPE SDS and Aseptic SetupRead a safety sheet, name the hazard, and match PPE to the body part at risk.Categorize Medical InterventionsSort medical interventions by what they do for a patient or population.Set Up A Lab NotebookSet up a lab notebook so another scientist can follow what happened.
Unit 1
Telling a sign from a symptomSort what a clinician can measure (signs) from what a patient reports (symptoms).Why antibiotics hit bacteria but not virusesConnect drug targets to cell structure to explain why antibiotics fail on viral infections.Building an outbreak claim from multiple evidence sourcesMake a claim-evidence-reasoning argument supported by independent lines of evidence, not a single clue.Reading a serial-dilution / ELISA standard curveUse a standard curve to turn an absorbance reading into a concentration.Build An Outbreak Line ListUse infection evidence to build an outbreak line list step by step.Classify PathogensUse infection evidence to classify pathogens step by step.Map Symptom Clusters to A HypothesisUse infection evidence to map symptom clusters to a hypothesis step by step.Interpret A BLAST Result E-value, CoverageUse molecular-test evidence to interpret a blast result (e-value, coverage) accurately.Read a DNA SequenceUse chromatogram peak evidence to read a DNA sequence accurately.Use Controls In IdentificationUse molecular-test evidence to use controls in identification accurately.Perform Serial DilutionsUse molecular-test evidence to perform serial dilutions accurately.Build A Standard CurveUse molecular-test evidence to build a standard curve accurately.Model Antigen Antibody BindingUse molecular-test evidence to model antigen-antibody binding accurately.Run An ELISA With ControlsUse molecular-test evidence to run an elisa with controls accurately.Distinguish Sensitivity vs SpecificityUse molecular-test evidence to distinguish sensitivity vs specificity accurately.Evaluate False Positive Negative RiskUse molecular-test evidence to evaluate false positive/negative risk accurately.Interpret Zone-of-Inhibition MICUse culture and antibiotic evidence to interpret zone-of-inhibition / mic.Explain Antibiotic MechanismUse culture and antibiotic evidence to explain antibiotic mechanism.Argue StewardshipUse culture and antibiotic evidence to argue stewardship.Apply Aseptic TechniqueUse infection evidence to apply aseptic technique step by step.Culture and Count ColoniesUse culture and antibiotic evidence to culture and count colonies.Explain Resistance Gene SpreadUse culture and antibiotic evidence to explain resistance gene spread.Interpret An AudiogramUse hearing or immune-response evidence to interpret an audiogram.Model Vaccine Immune ResponseUse infection evidence to model vaccine/immune response step by step.Calculate Herd Immunity ThresholdsUse hearing or immune-response evidence to calculate herd-immunity thresholds.
Unit 2
Read A PedigreeUse a genetics model to read a pedigree with clear limits.Interpret SNP DataRead a SNP table: compare alleles across people to find where two individuals differ or which SNP tracks a trait.Write A Genetic Counseling MemoStructure a genetic-counseling memo: state what the test shows, what it cannot prove (the limitation), and the recommended next step.Diagram A PCRDiagram a PCR cycle: order the three steps (denature, anneal, extend) and label what happens at each temperature.Interpret Gel BandsRead a gel: smaller DNA fragments travel farther (lower). Compare a band to the labeled ladder to estimate its size.Read A MicroarrayRead an expression microarray: each spot is a gene; the signal color tells you if it is up- or down-regulated versus a reference.Interpret An Expression Heat MapRead an expression heat map using the legend (red = high, blue = low) to tell which gene is up or down in a sample.Compute Fold ChangeUse molecular-test evidence to compute fold change accurately.Separate Risk From DiagnosisUse a genetics model to separate risk from diagnosis with clear limits.Compare Viral VectorsCompare AAV, lentivirus, and adenovirus on integration, payload size, and immune response to pick the best vector for a stated need.Distinguish Somatic vs Germline EditingUse gene-therapy evidence to distinguish somatic vs germline editing with ethical limits.Argue A CRISPR Ethics CERBuild a CER: identify the claim, the strongest evidence, and the reasoning in a CRISPR-ethics case, and pick the best-supported claim.Synthesize Testing to TreatmentUse molecular-test evidence to synthesize testing-to-treatment accurately.Evaluate Validity ReliabilityJudge whether evidence is trustworthy enough and name what limits the claim.Plan Treatment From DataUse patient evidence to plan treatment from data without overclaiming.
Unit 3
Relate Cancer to Loss Of RegulationWrite a short claim-evidence-reasoning paragraph from a small set of data.Classify Tumor TypesUse cancer evidence to classify tumor types from cell regulation through treatment planning.Build A Diagnostic WorkflowUse cancer evidence to build a diagnostic workflow from cell regulation through treatment planning.Compare Treatment OptionsUse cancer evidence to compare treatment options from cell regulation through treatment planning.Interpret StagingUse cancer evidence to interpret staging from cell regulation through treatment planning.Recommend A Treatment PlanUse evidence to recommend a treatment plan in a biomedical case.
Unit 4
Trace A Recombinant Protein WorkflowOrder the steps of making a human protein with recombinant DNA: gene to plasmid to host cells to expression to purification.Apply HLA Transplant MatchingUse organ-failure biotechnology evidence to apply hla/transplant matching.Compare Tissue Engineering OptionsUse organ-failure biotechnology evidence to compare tissue-engineering options.