Genetics of Disease (Medical Interventions)
Unit 1: Unit 1.3 to 1.4 Hearing & VaccinationMI 1.3-1.4Biotechnology Research and Experiments

Calculate Herd Immunity Thresholds

Use hearing or immune-response evidence to calculate herd-immunity thresholds.

Builds on (2 levels back)inferred · high confidence
  • Transmission basics: Outbreak work depends on agent, host, route, time, and place.
  • Case definition: Students need a rule for who counts as a case before counting cases.

Prerequisites are inferred: pending teacher review.

Re-learn the skill with worked practice and clear examples.

Practice the calculation across diseases. The bigger the R0, the higher the threshold. Use the table to check your work.

Step 1: Find R0
Read the R0 for the disease from the table.
Step 2: Compute 1 - 1/R0
Divide 1 by R0, subtract from 1, and convert the decimal to a percent.
Practice

Polio has R0 = 5 (see table). Using threshold = 1 - 1/R0, what percent of the population must be immune?

Reviewed
DiseaseR0Threshold = 1 - 1/R0
Flu20.50 (50%)
Polio50.80 (80%)
Measles100.90 (90%)
Table of diseases, R0 values, and herd-immunity thresholds
  1. A.80%
  2. B.20%
  3. C.75%
  4. D.95%
Show the worked solution ▾

Answer: A. 80%

  1. Step 1: Divide: 1 / 5 = 0.20.
  2. Step 2: Subtract and convert: 1 - 0.20 = 0.80 = 80%.

Why it's right: 1 - 1/5 = 1 - 0.20 = 0.80, which is 80%.

Why the others miss:
  • B: 20% is just 1/5 as a percent: you must subtract it from 100%.
  • C: 75% is the answer for R0 = 4, not R0 = 5.
  • D: 95% is the answer for R0 = 20, not R0 = 5.

Aligned to BRE: compute threshold for R0=5 · reading level ~grade 9

Where you'd see this
  • A vaccination drive sets an 80% coverage goal for a disease with R0 = 5.
Video library
Watch: Calculate Herd Immunity Thresholds
Herd Immunity Math
Manuel Mendoza
Guided notes

Fill these in as you work through the lesson.

Big idea: The herd-immunity threshold is the fraction of a population that must be immune to stop spread, and it equals 1 - 1/R0.
Key terms: write the meaning
  • R0 (people one case infects in an unprotected group):  
  • Herd-immunity threshold (immune fraction that stops spread):  
  • Immune (protected, cannot pass it on):  
  • Contagious (how easily it spreads):  
The rule

Herd-immunity threshold = 1 - (1 /  ). Convert the decimal to a   before comparing to a population.

Check yourself
  1. What is 1/R0 when R0 = 5? 
  2. What is 1 - 1/5 as a percent? 
  3. Why does a higher R0 need a higher threshold? 
Work one example

For R0 = 5, compute 1/R0, subtract from 1, and convert to a percent; then say whether a disease with R0 = 10 needs more or fewer people immune.