Thu, Nov 19, 2026Fall (Semester 1) · Week 13Day 59 of 6780-min block

Engineered-protein debate

Today's target

Argue whether engineered proteins made by cloned cells should be widely used and how they should be priced.

Due today · Exit ticket Required

Written final stance on engineered-protein access and pricing, plus a one-sentence rebuttal to the opposing strongest argument.

Your 4 steps today
  1. 1
    Do this
    Argue whether engineered proteins made by cloned cells should be widely used and how they should be priced.
  2. 2
  3. 3
    Submit this
    Exit ticket: Written final stance on engineered-protein access and pricing, plus a one-sentence rebuttal to the opposing strongest argument.
  4. 4
    Submit it here
    1. 1CMSD website. Go to clevelandmetroschools.org and click the Clever button.
    2. 2Clever. Clever opens. Sign in if it asks.
    3. 3Microsoft (district) login. Use your district Microsoft account (the one for school).
    4. 4Schoology. Open Schoology, then your class, then Assignments, and find the file named below.
    The file to submit is named: Genetics of Disease (Medical Interventions) › Plasmids, restriction enzymes, ligase, transformation, protein expression. › Exit ticket
    Open Schoology
Were you absent? Jump to the make-up plan
Where this fits
Tested on (Ohio WebXam)
Genetics of Disease · 072130
PLTW lesson
MI · Engineered-protein debate
WebXam domain
Bio-Molecular Technology
Evidence to produce
Exit ticket
Lab / skill
Genetic Science Learning Center: Cloning
Quick glossary
CER:
Claim, Evidence, Reasoning — make a claim, back it with evidence, explain your reasoning.
SOP:
Standard Operating Procedure — the exact steps to follow (especially in a lab).
Tracker:
Your PLTW progress log where you record completed evidence.
myPLTW:
The PLTW course site where you do the online activities — you open it through Schoology.
Learn first

Minute-by-minute · 80-minute block

💡 Big idea: Biotechnology that saves lives also raises questions about access, cost, and whose values guide regulation.

  1. 0-8Read briefing; note one benefit and one concern
  2. 8-15Choose stakeholder role; draft opening claim using recombinant protein
  3. 15-30Build evidence list for your claim
  4. 30-50Pair debate: swap and rebut
  5. 50-65Class vote and discussion
  6. 65-80Record final stance; async post if remote
Mr. Mendoza's 5-minute intro
  • Engineered proteins like insulin and growth hormone exist because scientists inserted human genes into bacteria.
  • The science works, but who benefits and who pays are still contested questions.
  • Today you argue from four stakeholder positions before you learn how the process actually works.
  • This bioethics framing ties directly to the Biotech Research domain of the 072130 WebXam.
Do this, step by step
  1. 1Read the engineered-protein briefing in the PLTW course shell and note one benefit and one concern.
  2. 2Pick a role: patient, biotech firm, regulator, or ethicist, and write your opening claim.
  3. 3Support your claim with one piece of evidence using the term recombinant protein.
  4. 4Write a rebuttal to a competing role's strongest argument.
  5. 5Record the class position and your personal stance with a reason.
You'll be able to
  • You'll be able to weigh benefits and concerns of engineered proteins.
  • You'll be able to defend a stance and respond to an objection.
Know by the end
  • Recombinant proteins are produced by host cells carrying an inserted human gene.
  • Engineered insulin transformed diabetes care but access remains unequal globally.
  • Pricing, intellectual property, and regulatory approval each reflect stakeholder values.
📺 Tutor me: Learn.Genetics: Gene Therapy and Cloning
Do the work

Your PLTW work today

Open this PLTW section today

Plasmids, restriction enzymes, ligase, transformation, protein expression. · Engineered-protein debate

Day 1 of this lesson. Open this exact section in myPLTW (reached through Schoology), then do the work below.

Do this: Open the engineered-protein debate activity in myPLTW for Lesson 4.1 Manufacturing Human Proteins, Activity 4.1.2 Protein Factories, and review the CER rubric.

Complete

Mark the debate entry complete and attach your stance note.

How far to get

Unit 4 overview reserve evidence should be submitted; this debate opens the cloning unit.

Upload as evidence

Written engineered-protein stance and rebuttal counted as one tracker evidence item.

All PLTW activities are completed inside the PLTW course environment — this page only gives direction. Submit producibles on Schoology.

The plan

Today's PLTW tracker

Check things off as you work, then submit. This tells Mr. Mendoza how you're doing so he can help the class. It does not replace turning in your producible on Schoology.

Use the code Mr. Mendoza gave you, not your name. Saved on this device.

Plasmids, restriction enzymes, ligase, transformation, protein expression.Day 1 of this projectSee the full week plan
Today's PLTW target

Plasmids, restriction enzymes, ligase, transformation, protein expression. · Engineered-protein debate

Open the engineered-protein debate activity in myPLTW for Lesson 4.1 Manufacturing Human Proteins, Activity 4.1.2 Protein Factories, and review the CER rubric.

Unit 4 overview reserve evidence should be submitted; this debate opens the cloning unit.

This is how Mr. Mendoza sees the class keeping pace with PLTW. Be honest, it only helps if it is accurate.

1 · What you do today

🎯 Argue whether engineered proteins made by cloned cells should be widely used and how they should be priced.

  • Read the engineered-protein briefing in the PLTW course shell and note one benefit and one concern.
  • Pick a role: patient, biotech firm, regulator, or ethicist, and write your opening claim.
  • Support your claim with one piece of evidence using the term recombinant protein.
  • Write a rebuttal to a competing role's strongest argument.
  • Record the class position and your personal stance with a reason.
2 · Turn in today

Exit ticket: Written final stance on engineered-protein access and pricing, plus a one-sentence rebuttal to the opposing strongest argument.

Submit on Schoology

Upload by 11:29 PM for full credit.

3 · Who's doing what (team)
TaskWho
Read the engineered-protein briefing in the PLTW course shell and note one benefit and one concern._______
Pick a role: patient, biotech firm, regulator, or ethicist, and write your opening claim._______
Support your claim with one piece of evidence using the term recombinant protein._______
Write a rebuttal to a competing role's strongest argument._______
Record the class position and your personal stance with a reason._______

Working solo? Put your own name in "Who" for every row.

4 · Words I can use correctly
5 · I'm successful today when I can…
  • You'll be able to weigh benefits and concerns of engineered proteins.
  • You'll be able to defend a stance and respond to an objection.
6 · Reflection & next steps
Where are you today?0/7 checked
Pick your period and code first.
Explore

Teacher-posted resources

Classroom documents for this lesson. Ones marked “Open the file” open right here; the rest are posted in Schoology. Use the label on each card to choose the right move.

Catch-up / reteachFor: Need extra support
pGLO Bacterial Transformation Quick Guide
worksheet/handoutOpens here
Open the file

Use this if you were absent, got stuck, or need another pass before you submit the lesson artifact.

Placement rationale

Matched Recombinant DNA and cloning workflow by path:Medical-Interventions/Unit-4_When-Organs-Fail/4.1_Manufacturing-Human-Proteins; keywords:transformation, pglo. Score 142. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).

Catch-up / reteachFor: Need extra support
Lesson 4.1 pGLO Workflow Graphic
worksheet/handoutOpens here
Open the file

Use this if you were absent, got stuck, or need another pass before you submit the lesson artifact.

Placement rationale

Matched Recombinant DNA and cloning workflow by path:Medical-Interventions/Unit-4_When-Organs-Fail/4.1_Manufacturing-Human-Proteins; keywords:transformation, pglo. Score 138. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).

Catch-up / reteachFor: Need extra support
Activity 4.1.2 pGLO Transformation Kit Quick Guide
worksheet/handoutOpens here
Open the file

Use this if you were absent, got stuck, or need another pass before you submit the lesson artifact.

Placement rationale

Matched Recombinant DNA and cloning workflow by path:Medical-Interventions/Unit-4_When-Organs-Fail/4.1_Manufacturing-Human-Proteins; keywords:transformation, pglo. Score 138. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).

How to get there: open the CMSD website, click Clever, sign in with your Microsoft (district) account, then open Schoology from Clever.

Lab day

Lab & supplies

Bring / set up
Plasmid and gene-insert models or DNA simulation kitRestriction enzyme and ligase reagents or model cardsMicropipette and tipsHost cell transformation simulation materialsSelection plate reference handoutSafety goggles and nitrile gloves
Genetic Science Learning Center: Cloning
Words

This unit's vocabulary

plasmid/PLAZ-mid/recombinant DNAligasetransformation/trans-for-MAY-shun/expression

Tap the speaker to hear a term. Weekly vocabulary task: add two of these terms to your notebook glossary with a definition and an example in your own words.

Check yourself

WebXam practice

Tap an answer to check it · nothing is recorded or graded
A plasmid is best described as
Which enzyme is responsible for sealing two pieces of DNA together to form recombinant DNA?
During bacterial transformation, calcium chloride and a heat shock are used to
Transformed bacteria are plated on agar containing an antibiotic because the plasmid also carries an antibiotic-resistance gene. This step
Check yourself

Cumulative WebXam review

A quick mixed-review pulling questions from earlier units plus today, so the WebXam material stays fresh.

Tap an answer to check it · nothing is recorded or graded
[Review: Molecule to Patient: Unit 2 Synthesis] A genetic counselor's main role on the health care team is to
[Review: When Cells Forget the Rules: Cancer Launch] When cancer cells break away and spread to other areas of the body, this process is called
[Review: From Biopsy to Plan: Treating Cancer] A tumor suppressor gene that cannot correct damage will trigger apoptosis. Apoptosis is
A plasmid is best described as
Explore

Where this leads — careers

What today's skills lead to. These are real health-science careers this course builds toward. Tap one to see, on the US Department of Labor's O*NET site, what the job actually involves, what it pays, and how fast it is growing.

Safety net

What to do if you were absent

Today was a debate — do this instead

Post a written engineered-protein argument from your stakeholder role in the course shell discussion, then reply to one classmate who took a different position.

Learn.Genetics: Gene Therapy and Cloning

Then submit your Exit ticket on Schoology.

If MR. MENDOZA is absent

Class still runs. Complete the online activity above (it's self-guided). Need the concept taught without a teacher? Use this authoritative explainer:

Genetic Science Learning Center: Cloning
Explore

Optional extra credit (async)

You've passed Unit 2, so the optional extra-credit track is open. Complete reserved-unit work from home (virtual labs included) for extra credit, all submitted on Schoology.

Open the extra-credit track
How this is graded
For: Exit ticket — Written final stance on engineered-protein access and pricing, plus a one-sentence rebuttal to the opposing strongest argument.
  • Complete
    Every required part of the artifact is present, nothing left blank.
  • Accurate
    The science and the data are correct and match the evidence.
  • Scientific reasoning
    You explain your claim with evidence and reasoning (CER), not just an answer.
  • Professional communication
    Clear, organized, labeled, and written the way a clinician or scientist would.
  • Submitted
    Turned in the right way (Schoology for routine work) and confirmed.
Submission Zone

Drop your Thu, Nov 19, 2026 · Engineered-protein debate here. Use a clear file name (your initials + project). Routine work still goes to Schoology (via the CMSD portal).

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