Fri, Apr 16, 2027Spring (Semester 2) · Week 13Day 56 of 6780-min block

Engineered organism debate

Today's target

Argue whether genetically engineering bacteria to produce medicine is ethically justified despite biosafety risks.

Due today · Exit ticket Required

One sentence stating whether engineered-organism benefit justifies biosafety risk, with a specific reason grounded in containment or patient benefit.

Your 4 steps today
  1. 1
    Do this
    Argue whether genetically engineering bacteria to produce medicine is ethically justified despite biosafety risks.
  2. 2
  3. 3
    Submit this
    Exit ticket: One sentence stating whether engineered-organism benefit justifies biosafety risk, with a specific reason grounded in containment or patient benefit.
  4. 4
    Submit it here
    1. 1CMSD website. Go to clevelandmetroschools.org and click the Clever button.
    2. 2Clever. Clever opens. Sign in if it asks.
    3. 3Microsoft (district) login. Use your district Microsoft account (the one for school).
    4. 4Schoology. Open Schoology, then your class, then Assignments, and find the file named below.
    The file to submit is named: Biotechnology for Health (Biomedical Innovations) › Recombinant DNA workflow, restriction enzymes, ligation, transformation safety. › Exit ticket
    Open Schoology
Were you absent? Jump to the make-up plan
Where this fits
Tested on (Ohio WebXam)
Biotechnology for Health and Disease · 072125
PLTW lesson
BI · Engineered organism debate
WebXam domain
Microbiology Testing and Technology
Evidence to produce
Exit ticket
Lab / skill
Learn.Genetics (University of Utah): cloning and recombinant DNA
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Read to prepare for today

Vetted sources picked for today's question. Skim these before you take a position or start the work, so your argument and evidence are grounded.

Quick glossary
CER:
Claim, Evidence, Reasoning — make a claim, back it with evidence, explain your reasoning.
SOP:
Standard Operating Procedure — the exact steps to follow (especially in a lab).
Tracker:
Your PLTW progress log where you record completed evidence.
myPLTW:
The PLTW course site where you do the online activities — you open it through Schoology.
Learn first

Minute-by-minute · 80-minute block

💡 Big idea: Genetic engineering offers medical benefits that must be weighed against biosafety risk.

  1. 0-5 minWarm-up: where does most insulin come from today?
  2. 5-20 minRead briefing on recombinant insulin bacteria; choose a position
  3. 20-40 minSmall-group debate tracking containment and patient-benefit claims
  4. 40-55 minFull-class debrief: which biosafety concern was hardest to dismiss?
  5. 55-70 minReflection: what safeguards would change your position?
  6. 70-80 minExit ticket: one sentence on whether benefit justifies risk, with a reason
Mr. Mendoza's 5-minute intro
  • Every medication made by bacteria started with someone deciding the benefit was worth the risk.
  • Today you argue that decision about insulin-producing E. coli from your own ethical position.
  • Strong arguments name specific biosafety controls and specific patient benefits, not just general feelings.
  • Tomorrow we get into the exact workflow that makes it possible, so today is your ethical foundation.
Do this, step by step
  1. 1Read the briefing on a recombinant bacterium engineered to make insulin.
  2. 2Choose a side on whether the benefit justifies the risk.
  3. 3List two reasons grounded in safety and patient benefit.
  4. 4Debate in your group, tracking claims about containment and oversight.
  5. 5Reflect on what safeguards would make you more comfortable.
You'll be able to
  • You defended a position on engineered-organism ethics.
  • You referenced biosafety and patient benefit.
Know by the end
  • Recombinant DNA technology inserts a human gene into a bacterial plasmid to produce a protein like insulin.
  • Containment levels and selection markers are engineering controls that reduce escape risk.
  • Ethical justification requires weighing patient benefit against probability and severity of harm.
📺 Tutor me: NHGRI: genetic engineering basics
Do the work

Your PLTW work today

Open this PLTW section today

Recombinant DNA workflow, restriction enzymes, ligation, transformation safety. · Engineered organism debate

Day 1 of this lesson. Open this exact section in myPLTW (reached through Schoology), then do the work below.

Do this: Open Problem 6 Molecular Biology in Action in your myPLTW course shell and navigate to the molecular biology ethics discussion activity.

Complete

Check off the molecular biology ethics discussion milestone in your activity tracker after submitting your reflection.

How far to get

You are starting Problem 6 on schedule; by end of today your reflection on engineered-organism ethics should be submitted.

Upload as evidence

Reflection paragraph attached as evidence of the discussion milestone.

All PLTW activities are completed inside the PLTW course environment — this page only gives direction. Submit producibles on Schoology.

The plan

Today's PLTW tracker

Check things off as you work, then submit. This tells Mr. Mendoza how you're doing so he can help the class. It does not replace turning in your producible on Schoology.

Use the code Mr. Mendoza gave you, not your name. Saved on this device.

Recombinant DNA workflow, restriction enzymes, ligation, transformation safety.Day 1 of this projectSee the full week plan
Today's PLTW target

Recombinant DNA workflow, restriction enzymes, ligation, transformation safety. · Engineered organism debate

Open Problem 6 Molecular Biology in Action in your myPLTW course shell and navigate to the molecular biology ethics discussion activity.

You are starting Problem 6 on schedule; by end of today your reflection on engineered-organism ethics should be submitted.

This is how Mr. Mendoza sees the class keeping pace with PLTW. Be honest, it only helps if it is accurate.

1 · What you do today

🎯 Argue whether genetically engineering bacteria to produce medicine is ethically justified despite biosafety risks.

  • Read the briefing on a recombinant bacterium engineered to make insulin.
  • Choose a side on whether the benefit justifies the risk.
  • List two reasons grounded in safety and patient benefit.
  • Debate in your group, tracking claims about containment and oversight.
  • Reflect on what safeguards would make you more comfortable.
2 · Turn in today

Exit ticket: One sentence stating whether engineered-organism benefit justifies biosafety risk, with a specific reason grounded in containment or patient benefit.

Submit on Schoology

Upload by 11:29 PM for full credit.

3 · Who's doing what (team)
TaskWho
Read the briefing on a recombinant bacterium engineered to make insulin._______
Choose a side on whether the benefit justifies the risk._______
List two reasons grounded in safety and patient benefit._______
Debate in your group, tracking claims about containment and oversight._______
Reflect on what safeguards would make you more comfortable._______

Working solo? Put your own name in "Who" for every row.

4 · Words I can use correctly
5 · I'm successful today when I can…
  • You defended a position on engineered-organism ethics.
  • You referenced biosafety and patient benefit.
6 · Reflection & next steps
Where are you today?0/7 checked
Pick your period and code first.
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Teacher-posted resources

Classroom documents for this lesson. Ones marked “Open the file” open right here; the rest are posted in Schoology. Use the label on each card to choose the right move.

Use during lessonFor: Everyone
BI Problem 6 Molecular Biology - Complete Module
worksheet/handoutOpens here
Open the file

Open this when the class reaches this activity and use it to complete the required lesson artifact.

Placement rationale

Matched Molecular biology workflow and cloning by path:Biomedical-Innovations/Problem-6_Molecular-Biology/00_Problem-Overview; keywords:molecular biology, recombinant dna. Score 146. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).

Use during lessonFor: Everyone
BI 6.1.2 Lab Module Organizer (Blank)
worksheet/handoutOpens here
Open the file

Open this when the class reaches this activity and use it to complete the required lesson artifact.

Placement rationale

Matched Molecular biology workflow and cloning by path:Biomedical-Innovations/Problem-6_Molecular-Biology/6.1_Molecular-Biology; keywords:recombinant dna, cloning. Score 142. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).

Catch-up / reteachFor: Need extra support
BI 6.1.2 Cloning Module 1 Ligation Overview
worksheet/handoutOpens here
Open the file

Use this if you were absent, got stuck, or need another pass before you submit the lesson artifact.

Placement rationale

Matched Molecular biology workflow and cloning by path:Biomedical-Innovations/Problem-6_Molecular-Biology/6.1_Molecular-Biology; keywords:recombinant dna, cloning. Score 142. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).

How to get there: open the CMSD website, click Clever, sign in with your Microsoft (district) account, then open Schoology from Clever.

Lab day

Lab & supplies

Bring / set up
Micropipettes and sterile tipsPlasmid DNA sampleRestriction enzyme and bufferDNA ligaseCompetent cellsMicrocentrifuge tubesPersonal protective equipment
Learn.Genetics (University of Utah): cloning and recombinant DNA
Words

This unit's vocabulary

recombinant DNArestriction enzymeligaseplasmid/PLAZ-mid/competent cell

Tap the speaker to hear a term. Weekly vocabulary task: add two of these terms to your notebook glossary with a definition and an example in your own words.

Check yourself

WebXam practice

Tap an answer to check it · nothing is recorded or graded
A lab assistant notices the calcium chloride for a bacterial transformation experiment expired three months ago but looks clear. What should they do?
You plate E. coli and notice a second, unexpected species grew after 24 hours. What most likely explains this?
You are plating bacteria for a transformation. When holding the plate, what should you wear to avoid contaminating the sample?
In which storage cabinet should you keep the rubbing (isopropyl) alcohol used to sterilize a molecular biology bench?
Check yourself

Cumulative WebXam review

A quick mixed-review pulling questions from earlier units plus today, so the WebXam material stays fresh.

Tap an answer to check it · nothing is recorded or graded
[Review: Reading the Data: graphs, trends, outliers, and correlation vs causation] Why should error bars be included on a graph of repeated environmental measurements?
[Review: Investigating an Outbreak: line lists, incidence, and intervention design] Which pair of terms correctly describes the difference between morbidity and mortality?
[Review: Communicating Public Health: audience, privacy, and evidence-based products] Usability testing of a health education website shows that users cannot find the main instructions. What should the team do?
A lab assistant notices the calcium chloride for a bacterial transformation experiment expired three months ago but looks clear. What should they do?
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Where this leads — careers

Safety net

What to do if you were absent

Today was a debate — do this instead

Post a 150-word stance on engineering bacteria to make medicine, then reply to a classmate who took the opposing view.

Then submit your Exit ticket on Schoology.

If MR. MENDOZA is absent

Class still runs. Complete the online activity above (it's self-guided). Need the concept taught without a teacher? Use this authoritative explainer:

Learn.Genetics (University of Utah): cloning and recombinant DNA
Explore

Optional extra credit (async)

You've passed Unit 2, so the optional extra-credit track is open. Complete reserved-unit work from home (virtual labs included) for extra credit, all submitted on Schoology.

Open the extra-credit track
How this is graded
For: Exit ticket — One sentence stating whether engineered-organism benefit justifies biosafety risk, with a specific reason grounded in containment or patient benefit.
  • Complete
    Every required part of the artifact is present, nothing left blank.
  • Accurate
    The science and the data are correct and match the evidence.
  • Scientific reasoning
    You explain your claim with evidence and reasoning (CER), not just an answer.
  • Professional communication
    Clear, organized, labeled, and written the way a clinician or scientist would.
  • Submitted
    Turned in the right way (Schoology for routine work) and confirmed.
Submission Zone

Drop your Fri, Apr 16, 2027 · Engineered organism debate here. Use a clear file name (your initials + project). Routine work still goes to Schoology (via the CMSD portal).

Upload a project