Thu, Feb 25, 2027Spring (Semester 2) · Week 6Day 26 of 6780-min block

Experimental vs observational

Today's target

Distinguish experimental from observational studies and choose the right design and sample size.

Due today · Pre-lab Required

Study design decision: experimental vs. observational classification with justification, plus a sample-size estimate and rationale for the Wednesday lab.

Your 4 steps today
  1. 1
    Do this
    Distinguish experimental from observational studies and choose the right design and sample size.
  2. 2
  3. 3
    Submit this
    Pre-lab: Study design decision: experimental vs. observational classification with justification, plus a sample-size estimate and rationale for the Wednesday lab.
  4. 4
    Submit it here
    1. 1CMSD website. Go to clevelandmetroschools.org and click the Clever button.
    2. 2Clever. Clever opens. Sign in if it asks.
    3. 3Microsoft (district) login. Use your district Microsoft account (the one for school).
    4. 4Schoology. Open Schoology, then your class, then Assignments, and find the file named below.
    The file to submit is named: Biotechnology for Health (Biomedical Innovations) › Experimental vs observational studies, sample size, graphing, mean, SD, t-test purpose. › Pre-lab
    Open Schoology
Were you absent? Jump to the make-up plan
Where this fits
Tested on (Ohio WebXam)
Biotechnology for Health and Disease · 072125
PLTW lesson
BI · Experimental vs observational
WebXam domain
Microbiology Testing and Technology
Evidence to produce
Pre-lab
Lab / skill
Khan Academy Statistics and Probability
Quick glossary
CER:
Claim, Evidence, Reasoning — make a claim, back it with evidence, explain your reasoning.
SOP:
Standard Operating Procedure — the exact steps to follow (especially in a lab).
Tracker:
Your PLTW progress log where you record completed evidence.
myPLTW:
The PLTW course site where you do the online activities — you open it through Schoology.
Learn first

Minute-by-minute · 80-minute block

💡 Big idea: Choosing the wrong study design before you collect data can make the data uninterpretable -- design decisions made now lock in what you will be able to conclude.

  1. 0-10Compare experimental and observational definitions with concrete physiology examples
  2. 10-25Classify three provided example studies as experimental or observational, with justification
  3. 25-45Decide which design fits your physiology question and write a one-paragraph justification
  4. 45-60Estimate a reasonable sample size and justify it in terms of expected variation
  5. 60-75Submit your design choice and sample-size rationale
  6. 75-80Exit check: could someone replicate your study design from your written description alone?
Mr. Mendoza's 5-minute intro
  • Yesterday you debated data ethics. Today you decide how you will actually design your study.
  • The two big questions are: experimental or observational? And how many trials?
  • Getting these decisions right before Wednesday's lab determines whether your data will be interpretable.
  • Study-design fluency is tested in the Molecular and Genetic Technology strand of WebXam 072125.
Do this, step by step
  1. 1Compare definitions of experimental and observational studies.
  2. 2Classify three example studies as experimental or observational.
  3. 3Decide which design fits your physiology question and why.
  4. 4Estimate a reasonable sample size and justify it.
  5. 5Submit your design choice and sample-size rationale.
You'll be able to
  • You can classify a study as experimental or observational.
  • You can justify a sample size for your design.
Know by the end
  • The defining difference between an experimental study (manipulated independent variable) and an observational study (no manipulation).
  • How to match a study design to a specific physiology question.
  • Why sample size affects both the reliability of results and the plausibility of your conclusions.
📺 Tutor me: Khan Academy Statistics and Probability
Do the work

Your PLTW work today

Open this PLTW section today

Experimental vs observational studies, sample size, graphing, mean, SD, t-test purpose. · Experimental vs observational

Day 2 of this lesson. Open this exact section in myPLTW (reached through Schoology), then do the work below.

Do this: Open Problem 2 in your myPLTW course shell and locate the study-design or experimental-design activity to review the expected format.

Complete

Mark the study-design activity complete in your tracker after submitting your design choice and sample-size rationale.

How far to get

The data-ethics CER is done; by end of today your experimental vs. observational design choice and sample-size rationale should be submitted.

Upload as evidence

Written study design choice with justification and a sample-size estimate and rationale for the Wednesday lab.

All PLTW activities are completed inside the PLTW course environment — this page only gives direction. Submit producibles on Schoology.

The plan

Today's PLTW tracker

Check things off as you work, then submit. This tells Mr. Mendoza how you're doing so he can help the class. It does not replace turning in your producible on Schoology.

Use the code Mr. Mendoza gave you, not your name. Saved on this device.

Experimental vs observational studies, sample size, graphing, mean, SD, t-test purpose.Day 2 of this projectSee the full week plan
Today's PLTW target

Experimental vs observational studies, sample size, graphing, mean, SD, t-test purpose. · Experimental vs observational

Open Problem 2 in your myPLTW course shell and locate the study-design or experimental-design activity to review the expected format.

The data-ethics CER is done; by end of today your experimental vs. observational design choice and sample-size rationale should be submitted.

This is how Mr. Mendoza sees the class keeping pace with PLTW. Be honest, it only helps if it is accurate.

1 · What you do today

🎯 Distinguish experimental from observational studies and choose the right design and sample size.

  • Compare definitions of experimental and observational studies.
  • Classify three example studies as experimental or observational.
  • Decide which design fits your physiology question and why.
  • Estimate a reasonable sample size and justify it.
  • Submit your design choice and sample-size rationale.
2 · Turn in today

Pre-lab: Study design decision: experimental vs. observational classification with justification, plus a sample-size estimate and rationale for the Wednesday lab.

Submit on Schoology

Upload by 11:29 PM for full credit.

3 · Who's doing what (team)
TaskWho
Compare definitions of experimental and observational studies._______
Classify three example studies as experimental or observational._______
Decide which design fits your physiology question and why._______
Estimate a reasonable sample size and justify it._______
Submit your design choice and sample-size rationale._______

Working solo? Put your own name in "Who" for every row.

4 · Words I can use correctly
5 · I'm successful today when I can…
  • You can classify a study as experimental or observational.
  • You can justify a sample size for your design.
6 · Reflection & next steps
Where are you today?0/7 checked
Pick your period and code first.
Explore

Teacher-posted resources

Classroom documents for this lesson. Ones marked “Open the file” open right here; the rest are posted in Schoology. Use the label on each card to choose the right move.

Catch-up / reteachFor: Need extra support
PLTW BI Mission 2.1 Research Design Progress Checklist
worksheet/handoutOpens here
Open the file

Use this if you were absent, got stuck, or need another pass before you submit the lesson artifact.

Placement rationale

Matched Human physiology data and research design by path:Biomedical-Innovations/Problem-2_Human-Physiology/2.1_Human-Physiology; keywords:physiology, research design. Score 142. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).

Catch-up / reteachFor: Need extra support
PLTW BI Mission 2.1 Research Design Checklist (docx)
worksheet/handoutOpens here
Open the file

Use this if you were absent, got stuck, or need another pass before you submit the lesson artifact.

Placement rationale

Matched Human physiology data and research design by path:Biomedical-Innovations/Problem-2_Human-Physiology/2.1_Human-Physiology; keywords:physiology, research design. Score 142. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).

Catch-up / reteachFor: Need extra support
PLTW BI Problem 2 Exploring Human Physiology Key Terms
worksheet/handoutOpens here
Open the file

Use this if you were absent, got stuck, or need another pass before you submit the lesson artifact.

Placement rationale

Matched Human physiology data and research design by path:Biomedical-Innovations/Problem-2_Human-Physiology/00_Problem-Overview; keywords:physiology, research design. Score 138. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).

How to get there: open the CMSD website, click Clever, sign in with your Microsoft (district) account, then open Schoology from Clever.

Lab day

Lab & supplies

Bring / set up
Heart-rate or pulse sensorLab computer or tablet with spreadsheet softwareStopwatch or timerData collection sheetCalculatorCleaning wipes for shared sensors
Khan Academy Statistics and Probability
Words

This unit's vocabulary

sample sizemeanstandard deviationt-testvalidityreliability

Tap the speaker to hear a term. Weekly vocabulary task: add two of these terms to your notebook glossary with a definition and an example in your own words.

Check yourself

WebXam practice

Tap an answer to check it · nothing is recorded or graded
To ensure preservation of incubated, refrigerated, and frozen substances, what should you closely monitor?
An analytical balance is used to weigh a 10g standard but displays 9.2g. What must be done?
Before performing maintenance, what should you verify on the glucometer test strips?
What is the purpose of an experiment measuring blood glucose after giving a drug or a placebo?
Check yourself

Cumulative WebXam review

A quick mixed-review pulling questions from earlier units plus today, so the WebXam material stays fresh.

Tap an answer to check it · nothing is recorded or graded
[Review: Finding the truth: credible sources, prior art, and needs assessment] After finding the experimental group had lower glucose than the placebo group, what is the next step?
[Review: Prototyping the ER: floor plans, process flow, and human factors] How should you properly prepare hydrochloric acid (HCl) for disposal?
[Review: Pitch and revise: evidence-based feedback and intro to study design] Experimental results fall significantly outside the expected range. What should you do first?
To ensure preservation of incubated, refrigerated, and frozen substances, what should you closely monitor?
Explore

Where this leads — careers

Safety net

What to do if you were absent

If YOU are absent

Today is individual PLTW work, so do exactly what we did in class, from home: complete the same PLTW target above, then submit your Pre-lab.

Open Schoology (CMSD) and keep going

How to get there: open the CMSD website, click Clever, sign in with your Microsoft (district) account, then open Schoology from Clever.

If MR. MENDOZA is absent

Class still runs. Complete the online activity above (it's self-guided). Need the concept taught without a teacher? Use this authoritative explainer:

Khan Academy Statistics and Probability
How this is graded
For: Pre-lab — Study design decision: experimental vs. observational classification with justification, plus a sample-size estimate and rationale for the Wednesday lab.
  • Complete
    Every required part of the artifact is present, nothing left blank.
  • Accurate
    The science and the data are correct and match the evidence.
  • Scientific reasoning
    You explain your claim with evidence and reasoning (CER), not just an answer.
  • Professional communication
    Clear, organized, labeled, and written the way a clinician or scientist would.
  • Submitted
    Turned in the right way (Schoology for routine work) and confirmed.
Submission Zone

Drop your Thu, Feb 25, 2027 · Experimental vs observational here. Use a clear file name (your initials + project). Routine work still goes to Schoology (via the CMSD portal).

Upload a project