Lab Manuals
Before the bench

Pre-lab simulations

Rehearse the reasoning, controls, safety decisions, and claim limits before you touch the equipment. Choose your course, then open the simulation named on your day page or lab manual.

Every course

71 active simulations · 1 archived
HAP

A Sieve Is Not a Kidney

Ohio course 072040; WebXam EFT0. Canonical portal curriculum route: hbs-patient-perspectives. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

1 block 2 sessions
BFH

Bioethics and the Belmont Report

Ohio course 072125; WebXam EGB5. Supplemental John Hay lab attached to locally verified live curriculum route: innovation-proposal. It is not represented as an official PLTW activity.

4 blocks 5 sessions
GenD

Biofeedback and the Autonomic Nervous System

Ohio course 072130; WebXam EGC0. Supplemental John Hay lab attached to locally verified live curriculum route: unit4-overview. It is not represented as an official PLTW activity.

2 blocks 4 sessions
BFH

Bioprinting a Scaffold

Ohio course 072125; WebXam EGB5. Supplemental John Hay lab attached to locally verified live curriculum route: prototype-validation. It is not represented as an official PLTW activity.

4 blocks 4 sessions
BFH

Building a Plasmid: Recombinant DNA by Cut and Paste

Ohio course 072125; WebXam EGB5. Locally verified live curriculum route: molecular-workflow, transformation-gel.

4 blocks 4 sessions
GenD

Building Better Bodies: What a Scaffold Is Worth

Ohio Genetics of Disease 072130 section 5.8, Biotechnology Research and Experiments, taken from the standards array on the portal's tissue-engineering day-page in deep-gend-c.ts. PLTW Medical Interventions Unit 4 tissue-engineering benchmark. The exact myPLTW activity number is provisional pending Manuel's authenticated myPLTW review.

2 blocks 2 sessions
GenD

Cancer Cell Morphology Under the Microscope

Ohio course 072130; WebXam EGC0. Locally verified live curriculum route: cancer-launch.

1 block 4 sessions
PBT

Class, or Identity?

Ohio course 072110; WebXam EGA0. Canonical portal curriculum route: pbs-scene. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

2 blocks 2 sessions
HAP

Counting a Virus by Plaque Assay

Ohio course 072040; WebXam EFT0. Canonical portal curriculum route: hbs-adventure-med. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

2 blocks 2 sessions
HAP

Cow Eye Dissection: Anatomy of Vision

Ohio course 072040; WebXam EFT0. Canonical portal curriculum route: hbs-adventure-med. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

1 block 1 session
BFH

Design and Test: Prototyping

Ohio course 072125; WebXam EGB5. Supplemental John Hay lab attached to locally verified live curriculum route: prototype-validation. It is not represented as an official PLTW activity.

2 blocks 4 sessions
GenD

Did the Resistance Actually Transfer?

Ohio course 072130; WebXam EGC0. Locally verified live curriculum route: culturing.

2 blocks 2 sessions
GenD

DNA/RNA Microarray: Reading Gene Expression

Ohio course 072130; WebXam EGC0. Locally verified live curriculum route: gene-expression.

1 block 5 sessions
GenD

ELISA: Diagnosing a Mystery Infection

Ohio course 072130; WebXam EGC0. Locally verified live curriculum route: elisa-lab.

2 blocks 2 sessions
BFH

Forensic Autopsy: Determining Cause of Death

Ohio course 072125; WebXam EGB5. Locally verified live curriculum route: forensic-project.

3 blocks 4 sessions
HAP

Fracture Analysis: What a Shadow Can and Cannot Tell You

Ohio course 072040 (Human Anatomy and Physiology); WebXam EFT0. Canonical portal curriculum route: hbs-bones, PLTW HBS Unit 1.1 Bones. The exact myPLTW activity number is unconfirmed pending Manuel's authenticated myPLTW review.

2 blocks 2 sessions
GenD

From Sample to Bands

Medical Interventions, Unit 2: How to Screen What is In Your Genes, Lesson 2.1 Genetic Testing and Screening, Activity 2.1.2 Copying Our Genes. Alignment status verified in myPLTW (see src/lib/curriculum/pltw-alignment.ts). Ohio course code 072130 Genetics of Disease; standards 5.4 Molecular and Genetic Technology and 5.5 Laboratory SOPs, taken from the testing-methods lesson's own standards array.

2 blocks 2 sessions
GenD

Gene Therapy: Vectors, Targets, and Ethics

Ohio course 072130; WebXam EGC0. Locally verified live curriculum route: gene-therapy.

2 blocks 4 sessions
HAP

Getting Nervous: Sheep Brain Dissection

Ohio course 072040; WebXam EFT0. Canonical portal curriculum route: hbs-nervous. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

2 blocks 5 sessions
BFH

Global Health Metrics

Ohio course 072125; WebXam EGB5. Supplemental John Hay lab attached to locally verified live curriculum route: public-health-product. It is not represented as an official PLTW activity.

4 blocks 4 sessions
GenD

Glow and Purify: Protein Purification

Ohio course 072130 (Genetics of Disease, taught as Medical Interventions). Lesson standards as declared on the portal route protein-purification: 072130 section 5.4 Molecular and Genetic Technology and section 5.5 Laboratory SOPs. The portal daily plan names myPLTW Activity 4.1.3 GFP Protein Purification; that activity number comes from the portal's own daily file and has not been checked against an authenticated myPLTW session.

2 blocks 2 sessions
HAP

Heart-Lung Pluck: Thoracic Anatomy in Situ

Ohio course 072040; WebXam EFT0. Canonical portal curriculum route: hbs-respiratory. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

1 block 1 session
HAP

Hello Kidney: The Urinalysis Story

Ohio course 072040; WebXam EFT0. Canonical portal curriculum route: hbs-patient-perspectives. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

2 blocks 5 sessions
PBT

Histology: The Four Tissue Types

Ohio course 072110; WebXam EGA0. Canonical portal curriculum route: pbs-morgue. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

2 blocks 4 sessions
HAP

How Many Is Too Many?

Ohio course 072040; WebXam EFT0. Canonical portal curriculum route: hbs-adventure-med. Anchored to lesson step 5, connect one expedition pathogen risk such as contaminated water to a prevention step. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

2 blocks 2 sessions
GenD

Is It Safe to Put In: the sterility release test

PLTW Medical Interventions, Unit 4 How to Prevail When Organs Fail, Lesson 4.4 Building a Better Body, Activity 4.4.2 Bionic Human. Aligned to the portal card for the tissue-engineering group. Runs as a simulation because no consumables were ordered for this course.

2 blocks 2 sessions
PBT

Is That Blood, or Barbecue Sauce?

Ohio course 072110; WebXam EGA0. Canonical portal curriculum route: pbs-scene. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

2 blocks 2 sessions
HAP

It Takes Guts: Enzyme Action

Ohio course 072040; WebXam EFT0. Canonical portal curriculum route: hbs-patient-perspectives. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

2 blocks 5 sessions
PBT

It Was Inert in the Beaker

Ohio course 072110; WebXam EGA0. Canonical portal curriculum route: pbs-innovation. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

1 block 2 sessions
PBT

It Worked in the Cup. Now What?

Ohio course 072110; WebXam EGA0. Canonical portal curriculum route: pbs-innovation-synthesis. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review. This is a supplemental John Hay lab, not represented as an official PLTW activity.

2 blocks 2 sessions
GenD

Making a Protein in Bacteria: GFP Transformation

Ohio course 072130; WebXam EGC0. Locally verified live curriculum route: cloning. Supplied lab source identifies MI Unit 4, Activity 4.1.2.

2 blocks 2 sessions
PBT

Medicine and Poison Are the Same Molecule

Ohio course 072110; WebXam EGA0. Canonical portal curriculum route: pbs-emergency. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

1 block 2 sessions
GenD

Minimally Invasive Surgery: Laparoscopic Skills

Ohio course 072130; WebXam EGC0. Supplemental John Hay lab attached to locally verified live curriculum route: organ-transplant. It is not represented as an official PLTW activity.

1 block 1 session
HAP

One Fiber Twitches. A Muscle Doesn't.

Ohio course 072040; WebXam EFT0. Canonical portal curriculum route: hbs-muscles. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

1 block 2 sessions
HAP

Read the Band Pattern

Ohio course 072040; WebXam EFT0. Canonical portal curriculum route: hbs-patient-perspectives. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

2 blocks 2 sessions
PBT

Read the Count. Name What It Cannot See.

Ohio course 072110; WebXam EGA0. Canonical portal curriculum route: pbs-dna-protein. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

1 block 2 sessions
PBT

Read the Family. Name the Pattern, and Name the Limit.

Ohio course 072110; WebXam EGA0. Canonical portal curriculum route: pbs-genetic-risk. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

1 block 2 sessions
BFH

Reading the Health of Water

Ohio course 072125; WebXam EGB5. Locally verified live curriculum route: environmental-graph.

2 blocks 2 sessions
GenD

Same Light, Two Strains: the DNA repair plate set

PLTW Medical Interventions, Unit 3 How to Conquer Cancer, Lesson 3.2 Reducing Your Risk, Project 3.2.2 Skin Cancer Prevention. Confirmed against the myPLTW course capture in audit-output/pltw-verify and the portal alignment card for the cancer-treatment group. Runs as a simulation because the room has no ultraviolet source and no consumables were ordered.

2 blocks 2 sessions
PBT

Sheep Heart Gross Anatomy: Dissection

Ohio course 072110; WebXam EGA0. Canonical portal curriculum route: pbs-morgue. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

1 block 1 session
GenD

Signs vs Symptoms: Building a Case Definition

Medical Interventions, Unit 1 How to Fight Infection, Lesson 1.1 The Mystery Infection, Activity 1.1.2 Investigating an Outbreak. Ohio course code 072130 (Genetics of Disease is the same course under its Ohio name). Alignment status V in the portal's PLTW alignment table. The outbreak week carries no standards array in the curriculum engine, so this lab claims no ODE or WebXam code.

2 blocks 2 sessions
GenD

Sunscreen and UV: Protecting Yeast from Damage

Ohio course 072130; WebXam EGC0. Supplemental John Hay lab attached to locally verified live curriculum route: cancer-launch. It is not represented as an official PLTW activity.

2 blocks 2 sessions
HAP

The Angle Is Not the Answer

Ohio course 072040; WebXam EFT0. Canonical portal curriculum route: hbs-motion-data. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

1 block 2 sessions
PBT

The Bellyache: Close It Honestly

Ohio course 072110; WebXam EGA0. Canonical portal curriculum route: pbs-diagnostic-workup. Method modeled on the Cleveland Clinic Dilemmas in Differential Diagnosis program. The patient and case are invented; no PLTW activity number is claimed.

2 blocks 2 sessions
HAP

The Dose You Never Tested

Ohio course 072040 (Human Anatomy and Physiology). Canonical portal curriculum route: hbs-challenge, the bound Wednesday investigation block. Anchored at the LESSON level only: PLTW publishes lesson-level names for HBS and no activity numbers, so no activity number and no activity title is asserted anywhere in this simulation. It is written to stand on its own science whether or not a matching PLTW activity or its kit is ever available.

2 blocks 2 sessions
GenD

The Drug That Does Nothing to Most People

Ohio course 072130, Genetics of Disease, which is the Ohio name for PLTW Medical Interventions. PLTW Unit 3 How to Conquer Cancer, Lesson 3.4 Building a Better Cancer Treatment. Locally verified live curriculum route: cancer-treatment.

2 blocks 2 sessions
PBT

The Glove That Failed

Shared across all four pathway courses. Ohio 072110 section 5.1 (PBS launch and orientation), 072040 section 5.5 (HBS launch and orientation), 072125 section 5.5 (BI launch and orientation), and 072130 section 5.5 (MI orientation and launch-safety). Canonical portal routes: the four orientation safety days plus pbs-launch, hbs-launch, bi-launch, and launch-safety. The exact myPLTW activity numbers remain unconfirmed pending Manuel's authenticated myPLTW review.

2 blocks 2 sessions
PBT

The Hour Nobody Wrote Down

Ohio course 072110, ODE 5.8 Biotechnology Research and Experiments and ODE 5.1 Handling, Preparation, Storage and Disposal, plus NGSS practices for planning investigations and analyzing data. Canonical portal curriculum route: pbs-infection, the outbreak investigation: line lists, epidemic curves, and identifying the agent.

2 blocks 2 sessions
HAP

The Muscle Quit, or Did the Brain?

Ohio course 072040; WebXam EFT0. Canonical portal curriculum route: hbs-muscles. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

2 blocks 2 sessions
GenD

The Ruler You Make Yourself

Ohio course 072130, Genetics of Disease, which is the same course PLTW calls Medical Interventions. Unit 1 How to Fight Infection, Lesson 1.1 The Mystery Infection, Activity 1.1.5 ELISA, alignment status verified in src/lib/curriculum/pltw-alignment.ts. Canonical portal curriculum route: elisa-dilution, anchored to the Tuesday day-page 'Concentration and serial dilution'. Standards quoted verbatim from that lesson's own standards array: 072130 section 5.4 Molecular and Genetic Technology and section 5.5 Laboratory SOPs. No WebXam subcode is asserted, because none was opened for this build.

2 blocks 2 sessions
GenD

The Score That Lies

Ohio course 072130; WebXam EGC0. Supplemental John Hay lab attached to locally verified live curriculum route: unit4-overview. It is not represented as an official PLTW activity.

1 block 2 sessions
GenD

The Screen Said Yes

Ohio course 072130, Genetics of Disease, which is the same course PLTW calls Medical Interventions. Unit 2 How to Screen What is In Your Genes, Lesson 2.2 Our Genetic Future. Canonical portal curriculum route: unit2-synthesis. Standards used verbatim from that lesson: Genetics of Disease 072130 section 5.8, and NGSS argumentation from evidence. No lab-specific subcode and no WebXam code is asserted; the exact myPLTW activity number awaits Manuel's authenticated myPLTW review.

2 blocks 2 sessions
HAP

The Track Shows What, Not Who

Ohio course 072040; WebXam EFT0. Canonical portal curriculum route: hbs-endocrine. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review. This is a supplemental John Hay lab, not represented as an official PLTW activity.

2 blocks 2 sessions
BFH

The Tube That Did Not Light Up

PLTW Biomedical Innovation, Problem 4 Investigating Environmental Health, Activity 4.1.2 Analysis of Water Contamination. Verified against the sourced page-by-page extract of the live myPLTW Teacher Guide taken 2026-08-06, including the activity number, the activity title, the Edvotek Kit #951 five-tube coliform panel, the 0.8 mL volumes, the overnight 37 degree Celsius incubation and the color then ultraviolet then indole read order. Ohio course code is unresolved between 072125 Biotechnology for Health and Disease and 072110 Principles and Practice of Biomedical Technology, so outcomes are declared for both.

2 blocks 2 sessions
HAP

What a Normal Breathing Test Cannot Tell You

Ohio course 072040; WebXam EFT0. Canonical portal curriculum route: hbs-respiratory. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

1 block 2 sessions
PBT

What Does a Normal Reading Mean?

Ohio course 072110; WebXam EGA0. Canonical portal curriculum route: pbs-clinical-comm. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

1 block 2 sessions
HAP

What Does the Strip Actually See?

Ohio course 072040; WebXam EFT0. Canonical portal curriculum route: hbs-patient-perspectives. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

2 blocks 2 sessions
GenD

What Does the Zone Mean?

Ohio course 072130; WebXam EGC0. Locally verified live curriculum route: antibiotics.

2 blocks 2 sessions
GenD

What Genotype Does a Taste Let You Claim?

Ohio course 072130; WebXam EGC0. Locally verified live curriculum route: genetic-testing.

1 block 2 sessions
BFH

What Is the Band Allowed to Mean?

Ohio course 072125; WebXam EGB5. Locally verified live curriculum route: environmental-exposure.

2 blocks 2 sessions
PBT

What Is the Match Allowed to Mean?

Ohio course 072110; WebXam EGA0. Canonical portal curriculum route: pbs-evidence-biomolecules. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

2 blocks 2 sessions
BFH

What Is the Recovery Number Really Telling You?

Ohio course 072125; WebXam EGB5. Locally verified live curriculum route: er-present-physiology, physiology-data, physiology-analysis.

1 block 2 sessions
HAP

What Is This Trace Allowed to Say?

Ohio course 072040; WebXam EFT0. Canonical portal curriculum route: hbs-cardio. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

1 block 2 sessions
HAP

Where in the Loop Is the Delay?

Ohio course 072040; WebXam EFT0. Canonical portal curriculum route: hbs-reflexes. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

1 block 2 sessions
BFH

Where Is the Line?

Ohio course 072125; WebXam EGB5. Locally verified live curriculum route: environmental-exposure, environmental-graph.

2 blocks 2 sessions
GenD

Who Does the Threshold Protect?

Ohio course 072130; WebXam EGC0. Locally verified live curriculum route: hearing-vaccine.

2 blocks 2 sessions
PBT

Who Is on the Plate?

Ohio course 072110; WebXam EGA0. Canonical portal curriculum route: pbs-outbreak. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

2 blocks 2 sessions
BFH

Who Was Patient Zero?

Ohio course 072125; WebXam EGB5. Locally verified live curriculum route: public-health-intervention.

1 block 2 sessions
HAP

Whose Bacteria Is That?

Ohio course 072040, Human Anatomy and Physiology, WebXam blueprint in src/lib/webxam.ts: Culturing 8.16 percent, Microbiology Testing and Technology 13.27 percent, Laboratory Standard Operational Procedures 4.08 percent. Standards carried by the hbs-immune lesson in deep-hbs-b.ts and used here: 072040 2.2 Evaluate Body Systems and 072040 5.3 Microbiology. 072040 5.6 Culturing is NOT carried by hbs-immune and is therefore not claimed on this sim. Canonical portal route: hbs-immune. The exact myPLTW activity association is a Manuel authenticated-review gate.

2 blocks 2 sessions
PBT

Whose DNA, and Does It Even Matter?

Ohio course 072110; WebXam EGA0. Canonical portal curriculum route: pbs-evidence-biomolecules. The exact myPLTW activity number remains unconfirmed pending Manuel's authenticated myPLTW review.

1 block 2 sessions
BFH

You Cannot Ask a Crowd a Question

PLTW Biomedical Innovation, Problem 4 Investigating Environmental Health, unit 4.1. Sits between the two verified halves of Activity 4.1.2 Analysis of Water Contamination: the Edvotek Kit #951 coliform broth panel that returns a positive, and the Edvotek Kit #953 multiplex PCR that names a strain. Both halves are confirmed against the sourced myPLTW Teacher Guide extract of 2026-08-06. PLTW's own kit performs this isolation step for the class by supplying three pre-made cultures with names already on the labels, so this simulation asserts NO PLTW activity number and NO PLTW activity title for the plating, the streaking or the colony reading. Ohio course code is unresolved between 072125 Biotechnology for Health and Disease and 072110 Principles and Practice of Biomedical Technology, so outcomes are declared for both.

2 blocks 2 sessions