Rough draft.This research track is under review with Dr. Atit's lab. Content and sequence may still change.
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Curriculum and WebXam connections
ClinVar: which IRF6 changes cause disease?
How this session lines up with the PLTW curriculum and the WebXam for each class it touches, including the vocabulary, concepts, and skills you share.
The classes below may be taught in different terms. This research track runs all year with HOSA, so a connection means the ideas line up, not that the class meets this week.
GenDGenetics of Disease Fall and Spring
PLTW alignment
GenD's genetic-testing work classifies variants by clinical significance.
WebXam
072130 Genetics of Disease
Domain: Bio-Molecular Technology
How it connects
ClinVar is the database behind the genetic-testing decisions GenD teaches.
Shared concepts
Pathogenic vs uncertainVariant interpretation
Shared skills
Search ClinVarRead a variant record
Shared vocabulary (same words, same meaning)
- mutation mirrors: Mutations and their effects
- gene mirrors: Genes code for proteins
- phenotype mirrors: Genotype to phenotype
BIBiomedical Innovations Spring
PLTW alignment
BI research can survey and analyze variant data.
WebXam
072125 Biotechnology for Health and Disease
Domain: Bio-Molecular Technology
How it connects
A ClinVar survey is a clean BI data-analysis project.
Shared concepts
Variant surveyData classification
Shared skills
Tabulate and classify variants