John Hay
John Hay Biomedical
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Here's an example of what's due today

DNA and protein modeling

Fri, Oct 23, 2026 · Week 9 · Principles of Biomedical Technology (Principles of Biomedical Science)

Today's goal: Model transcription and translation following an SOP and introduce a mutation to observe its effect.

Learn first

What a finished product looks like

This is a model of the work you should turn in today. Use it to check your own: match the structure and the level of detail, do not copy it. Your data and wording should be your own.

Transcription-translation lab notebook entry
Completes: A lab notebook entry showing the original DNA template, the mRNA, the original amino acid sequence with codon-chart citations, the mutated sequence, the mutation type with justification, and one model limitation.

Lab notebook entry (Patient A gene model):

  • Original DNA template (3'-5'): T A C A C C G A G
  • mRNA (5'-3'): A U G U G G C U C
  • Original amino acids (codon chart): Met (AUG, start) - Trp (UGG) - Leu (CUC)
  • Point mutation introduced: DNA template ACC changed to ACA, so mRNA UGG becomes UGU
  • Mutated amino acids: Met - Cys (UGU) - Leu
  • Mutation type: missense. Justification: one base changed, which changed one codon, which changed one amino acid (Trp to Cys) without making a stop codon.
  • Limitation: the model shows the amino acid sequence but cannot show how the protein folds in 3D, so it cannot prove how much function is lost.
VersionmRNA codonsAmino acids
OriginalAUG UGG CUCMet Trp Leu
MutatedAUG UGU CUCMet Cys Leu
ChangeUGG to UGUTrp to Cys (missense)
Table comparing original and mutated mRNA codons and the resulting amino acids, showing a missense change.

Also due today: Photograph the notebook entry and upload to the tracker before leaving class.

Check yourself

WebXam problem for today's skill

One exam-style question that uses exactly what you practiced today. Try it before you reveal the answer, then read why each choice is right or wrong.

WebXam-style domain: Biotechnology Research and ExperimentsSelf-check skill: Classifying a point mutation as silent, missense, or nonsense
A point mutation changes an mRNA codon from UGG (Trp) to UGA. What type of mutation is this?

Tap an answer to see the full explanation. Nothing is recorded or graded.

Back to today's lesson