Karyotype case analysis
Students individually arrange and interpret a karyotype to identify a chromosomal abnormality in a patient case.
Completed karyotype template with labeled chromosome pairs, identified abnormality, and one stated procedural limitation.
- 1Do thisStudents individually arrange and interpret a karyotype to identify a chromosomal abnormality in a patient case.
- 2Use this resource
- 3Submit thisLab report: Completed karyotype template with labeled chromosome pairs, identified abnormality, and one stated procedural limitation.
- 4Submit it here
- 1CMSD website. Go to clevelandmetroschools.org and click the Clever button.
- 2Clever. Clever opens. Sign in if it asks.
- 3Microsoft (district) login. Use your district Microsoft account (the one for school).
- 4Schoology. Open Schoology, then your class, then Assignments, and find the file named below.
The file to submit is named: Principles of Biomedical Technology (Principles of Biomedical Science) › Unit 2.2 to 2.3: Chromosomal abnormalities, genetic risk, family evidence, diagnosis from mixed data. › Lab reportOpen Schoology
- CER:
- Claim, Evidence, Reasoning — make a claim, back it with evidence, explain your reasoning.
- SOP:
- Standard Operating Procedure — the exact steps to follow (especially in a lab).
- Tracker:
- Your PLTW progress log where you record completed evidence.
- myPLTW:
- The PLTW course site where you do the online activities — you open it through Schoology.
Minute-by-minute · 80-minute block
💡 Big idea: A karyotype is a diagnostic tool: the accuracy of the result depends on following a precise SOP and recognizing sources of error.
- 0-5 minReview SOP posted at station: cutting, pairing, and mounting sequence.
- 5-10 minIdentify and record independent variable (chromosome images given) and dependent variable (completed karyotype reading).
- 10-50 minIndividual karyotype construction: sort 22 autosome pairs plus sex chromosomes; mount on template.
- 50-65 minCompare to reference karyotype; identify and name the chromosomal abnormality.
- 65-75 minRecord one source of procedural error that could affect the diagnosis.
- 75-80 minSubmit completed karyotype and written abnormality statement before leaving.
- • Today you are the clinical cytogenetics technician: your karyotype reading is what the genetic counselor will use.
- • Follow the SOP exactly, sequence matters just as it does in a real lab.
- • This is a Handling/Preparation/Storage/Disposal skill (WebXam 072110 strand 1): precision and documentation count.
- • When you identify the abnormality, write it down in proper clinical language.
- 1Record the SOP for cutting, pairing, and ordering chromosome images.
- 2Identify the independent and dependent variables in this diagnostic procedure.
- 3Sort chromosomes by size and centromere position into 22 pairs plus sex chromosomes.
- 4Compare the completed karyotype to a reference to detect any extra or missing chromosome.
- 5Name the abnormality and note one source of error that could affect the reading.
- • Produce a correctly ordered karyotype following the lab SOP.
- • Identify the chromosomal abnormality and state one procedural limitation.
- • Chromosomes are paired by homologs using size, banding pattern, and centromere position.
- • An extra or missing chromosome detected in a karyotype indicates a numerical abnormality.
- • Procedural errors in cutting, pairing, or image quality can produce a false reading.
Your PLTW work today
Unit 2.2 to 2.3: Chromosomal abnormalities, genetic risk, family evidence, diagnosis from mixed data. · Karyotype case analysis
Day 3 of this lesson. Open this exact section in myPLTW (reached through Schoology), then do the work below.
Do this: Open myPLTW and locate the Lesson 2.2 Decoding a Diagnosis karyotype activity. Use the platform's reference images to verify your chromosome pairing.
Record your abnormality finding in the platform response field and submit.
You finished the chromosomal-abnormalities task Tuesday. Today you should reach the abnormality-identification question and submit it.
Completed paper karyotype plus platform submission count as your evidence.
All PLTW activities are completed inside the PLTW course environment — this page only gives direction. Submit producibles on Schoology.
Today's PLTW tracker
Check things off as you work, then submit. This tells Mr. Mendoza how you're doing so he can help the class. It does not replace turning in your producible on Schoology.
Use the code Mr. Mendoza gave you, not your name. Saved on this device.
Unit 2.2 to 2.3: Chromosomal abnormalities, genetic risk, family evidence, diagnosis from mixed data. · Karyotype case analysis
Open myPLTW and locate the Lesson 2.2 Decoding a Diagnosis karyotype activity. Use the platform's reference images to verify your chromosome pairing.
You finished the chromosomal-abnormalities task Tuesday. Today you should reach the abnormality-identification question and submit it.
This is how Mr. Mendoza sees the class keeping pace with PLTW. Be honest, it only helps if it is accurate.
🎯 Students individually arrange and interpret a karyotype to identify a chromosomal abnormality in a patient case.
- Record the SOP for cutting, pairing, and ordering chromosome images.
- Identify the independent and dependent variables in this diagnostic procedure.
- Sort chromosomes by size and centromere position into 22 pairs plus sex chromosomes.
- Compare the completed karyotype to a reference to detect any extra or missing chromosome.
- Name the abnormality and note one source of error that could affect the reading.
Lab report: Completed karyotype template with labeled chromosome pairs, identified abnormality, and one stated procedural limitation.
Submit on SchoologyUpload by 11:29 PM for full credit.
| Task | Who |
|---|---|
| Record the SOP for cutting, pairing, and ordering chromosome images. | _______ |
| Identify the independent and dependent variables in this diagnostic procedure. | _______ |
| Sort chromosomes by size and centromere position into 22 pairs plus sex chromosomes. | _______ |
| Compare the completed karyotype to a reference to detect any extra or missing chromosome. | _______ |
| Name the abnormality and note one source of error that could affect the reading. | _______ |
Working solo? Put your own name in "Who" for every row.
- Produce a correctly ordered karyotype following the lab SOP.
- Identify the chromosomal abnormality and state one procedural limitation.
Resources & readings
Hand-picked materials for this lesson. Class file items open the document directly; the rest are vetted readings and interactives from other biomedical programs.
Lab & supplies
- • Handle scissors with blade pointing down when moving.
- • Keep workspace clear of loose scraps to avoid contaminating another student's karyotype.
- • Wash hands after handling printed lab materials.
WebXam practice
Cumulative WebXam review
A quick mixed-review pulling questions from earlier units plus today, so the WebXam material stays fresh.
Where this leads — careers
What today's skills lead to. These are real health-science careers this course builds toward. Tap one to see, on the US Department of Labor's O*NET site, what the job actually involves, what it pays, and how fast it is growing.
What to do if you were absent
Today is individual PLTW work, so do exactly what we did in class, from home: complete the same PLTW target above, then submit your Lab report.
Open Schoology (CMSD) and keep goingHow to get there: open the CMSD website, click Clever, sign in with your Microsoft (district) account, then open Schoology from Clever.
Class still runs. Complete the online activity above (it's self-guided). Need the concept taught without a teacher? Use this authoritative explainer:
NHGRI genome.govOptional extra credit (async)
You've passed Unit 2, so the optional extra-credit track is open. Complete reserved-unit work from home (virtual labs included) for extra credit, all submitted on Schoology.
Open the extra-credit track- CompleteEvery required part of the artifact is present, nothing left blank.
- AccurateThe science and the data are correct and match the evidence.
- Scientific reasoningYou explain your claim with evidence and reasoning (CER), not just an answer.
- Professional communicationClear, organized, labeled, and written the way a clinician or scientist would.
- SubmittedTurned in the right way (Schoology for routine work) and confirmed.
Drop your Fri, Oct 23, 2026 · Karyotype case analysis here. Use a clear file name (your initials + project). Routine work still goes to Schoology (via the CMSD portal).
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