Rough draft.This research track is under review with Dr. Atit's lab. Content and sequence may still change.
The Baby Mateo Case
Anatomical domainHuman Body Systems (HBS)Lesson 20 of 20Your seat: Whole Craniofacial Team (Domain Report)

Mateo's Complete Anatomical and Surgical Story

Discovery question

When we assemble Mateo's whole anatomical and surgical picture, what exactly does he have, and how do we know it is that and not something larger?

💡 Every finding stayed inside the region, so the assembled evidence names an isolated, nonsyndromic complete CL/P, .

The plan

Prerequisite check

Before this page, you should know
  • A child like Mateo is cared for by a multidisciplinary team working in a planned order called , each stage timed to growth, not a calendar date.
  • The usual order is NAM in the first weeks, lip repair around 3 to 6 months, repair around 10 to 14 months, then ear and speech surveillance, then alveolar bone graft in the before age 9, then bite and nose at .
Today's new idea is only
Every finding stayed inside the region, so the assembled evidence names an isolated, nonsyndromic complete CL/P, .
Learn first

What you will learn

Goal: Synthesize the anatomical domain into one account of Mateo's case and reason from the assembled evidence to the diagnosis of an isolated, nonsyndromic complete CL/P ().

Know by the end
  • Mateo has a complete (left) of the lip, , and , classified as .
  • Told as : the orbicularis ring and the levator sling are interrupted (form), surgery rebuilds them (repair), and the team watches for fistula, VPI, ear fluid, and a missing (consequence).
  • Every finding across the domain stayed inside the region; the found no other birth defects.
  • A not part of a larger condition is isolated; not belonging to a named syndrome is nonsyndromic. Severity is not the same as syndromic.
Learn first

Model: Mateo's case file as one story, and the two profiles side by side

Read Mateo's case file as one continuous story: form, then repair, then consequence. A of the left lip, , and (primary and secondary palate, one side) is classified . The ring was interrupted at the lip and inserted on the margins, so at about 3 to 6 months rebuilt the ring. The failed to form its sling, so at about 10 to 14 months rebuilt the sling. The gap in the gum left no bony home for the canine, so an alveolar bone graft in the (before age 9) filled it. The team then watched for consequences: a residual fistula or VPI (the Veau III fistula rate is about 8.3 percent), expected middle-ear fluid that is acquired after birth, and the at the cleft as the most affected tooth.

Now compare two profiles. If Mateo had a larger, syndromic condition, you would often expect defects beyond the region (heart, limbs, eyes, growth, other organs), affected structures spread across the body, and a pattern pointing to one named disease. Mateo's actual record shows the opposite: the found no other birth defects, every affected structure sat in the lip, , and nearby tissues, and in nineteen lessons no second feature ever appeared. His whole anatomical record sits entirely in the isolated column.

So the diagnosis you earn from the assembled evidence is an isolated, nonsyndromic complete CL/P, . Note carefully: the is severe, but severity is not the same as syndromic. An isolated is common, and its prevalence varies by ancestry. The alone cannot name a gene, but it can rule the picture in as isolated, which is exactly the breadcrumb the other domains needed.

Read this in pieces, one chunk at a time
Do the work

Explore (work the model before reading on)

  1. What classification did the team assign to Mateo's , and what does it stand for?
  2. Did any finding in this domain ever appear outside the lip, , and nearby structures?
  3. Walk the case file as one story: state one form problem, the repair for it, and one possible consequence, in your own words.
  4. The is severe (a complete ), yet it is the only defect. Why does severe not mean syndromic?
  5. A classmate says a this complete must signal a bigger disease. Write the one piece of evidence that most directly answers them.
The plan

Guided notes

1

The diagnosis, told as a story

Model start: Mateo has a complete left of the lip, , and , classified , told as form, then repair, then consequence.
  • Form: the and the levator ____ are interrupted; repair rebuilds the lip ring and the palatal sling.
  • Consequence: the team watches for fistula, VPI, ear fluid, and a missing ____ incisor.
2

Isolated, not syndromic

  • Every finding stayed inside the region, and the found ____ (no) other birth defects.
  • A not part of a larger condition is ____ (isolated), and not belonging to a named syndrome is nonsyndromic.
3

Severity vs syndromic

  • The is severe, but severity is ____ (not) the same as syndromic; an isolated is common and varies by ancestry.
Explore

Reading the Research

Why this source matters
This is the published evidence behind today's idea: Every finding stayed inside the region, so the assembled evidence names an isolated, nonsyndromic complete CL/P, .
Words to unlock first
isolated cleftnonsyndromicVeau IIIform-repair-consequencedomain synthesis
Reading moves
  1. Skim the title and abstract first to get the gist.
  2. Circle the one sentence that states the main claim.
  3. Box the evidence the authors give for that claim.
  4. Mark one sentence that confuses you, and move on.
Stop point
You do not need the methods or statistics yet. If a sentence is about lab technique or math you have not learned, mark it and skip it.
Your output
Write one claim-evidence sentence: what this source claims, and the one piece of evidence that backs it up.
Where this fits
Tested on (Ohio WebXam)
Genetics of Disease · 072130
PLTW lesson
MI · Anatomical domain · Integrating structure, function, and intervention across a body region
WebXam domain
Bio-Molecular Technology
Evidence to produce
Write Mateo's anatomical Domain Report in one short paragraph (five to seven sentences). It must (1) name the diagnosis, (2) tell it as form, then repair, then consequence, and (3) end with the one sentence of evidence that makes it isolated rather than syndromic. This paragraph is your team's deliverable to the rest of the case.
Lab / skill
Human Body Systems (HBS) · Principles of Biomedical Science (PBS)
Words

Vocabulary (the same words your classes use)

The plan

Track your progress today

Check these off as you work through the lesson, then submit. This tells Mr. Mendoza how you're doing so he can help the class. It does not replace turning in your producible.

Use the code Mr. Mendoza gave you, not your name. Saved on this device.

Check off as you finish
  • Read the Model and answered the Explore questions.
  • Filled in the guided notes in my own words.
  • Defined the new vocabulary with an example.
  • Built the producible: Write Mateo's anatomical Domain Report in one short paragraph (five to seven sentences). It must (1) name the diagnosis, (2) tell it as form, then repair, then consequence, and (3) end with the one sentence of evidence that makes it isolated rather than syndromic. This paragraph is your team's deliverable to the rest of the case.
  • Wrote my Claim, Evidence, and Reasoning exit ticket.
Pick your period and code first.
Check yourself

Exit ticket (Claim, Evidence, Reasoning)

  • Claim: Mateo has an isolated, nonsyndromic complete CL/P, .
  • Evidence: Cite the classification and the key absence (no other birth defects), plus one repair and one consequence.
  • Reasoning: Explain why an absence of findings outside the region is the strongest anatomical evidence that the cleft is isolated, not a sign of a larger syndrome.
How this is graded (rubric)
For: Write Mateo's anatomical Domain Report in one short paragraph (five to seven sentences). It must (1) name the diagnosis, (2) tell it as form, then repair, then consequence, and (3) end with the one sentence of evidence that makes it isolated rather than syndromic. This paragraph is your team's deliverable to the rest of the case.
CriterionProficientDevelopingBeginning
CompleteEvery required part of the artifact is present and filled in.Most parts are present, but one is missing or left blank.Several parts are missing.
AccurateThe science and data are correct and match the evidence.Mostly correct, with a small factual slip.Key science or data is wrong.
Scientific reasoning (CER)States a claim, backs it with specific evidence, and explains the reasoning.Has a claim and evidence, but the reasoning is thin or missing.Gives an answer with no evidence or reasoning.
Professional communicationClear, organized, and labeled the way a clinician or scientist would write it.Readable but disorganized or missing labels.Hard to follow.
SubmittedTurned in the right way (Schoology for routine work) and confirmed.Turned in, but in the wrong place or unconfirmed.Not turned in.
How the model answer scores against this rubric
  • CompleteProficient: Nothing is left blank: the model fills every part of "Write Mateo's anatomical Domain Report in one short paragraph (five to seven sentences). It must (1) name the diagnosis, (2) tell it as form, then repair, then consequence, and (3) end with the one sentence of evidence that makes it isolated rather than syndromic. This paragraph is your team's deliverable to the rest of the case.".
  • AccurateProficient: Every number and claim matches the case evidence.
  • Scientific reasoning (CER)Proficient: It names a claim, cites the specific evidence, and explains the reasoning, not just the answer.
  • Professional communicationProficient: It is organized and labeled like a real chart note.
  • SubmittedProficient: It would be turned in on Schoology and confirmed.
Explore

Where this leads: careers

Craniofacial Surgeon Clinical Geneticist

What's next: The anatomical and surgical team has finished its report. But isolated and nonsyndromic is the 's verdict, not the whole answer. The clinical team can describe the lifelong care, the genetics team can ask why the formed at all, and the developmental team can show the moment failed. We hand them our complete picture, and every team's story points to the same conclusion.