Mateo's Complete Developmental Story
Developmental domain · Lesson 20 of 20 · Principles of Biomedical Science (PBS)
Today's goal: Assemble the twenty-lesson evidence into one normal-versus-failed developmental account of Mateo's cleft, and conclude that it is an isolated failure of fusion in a specific window (nonsyndromic, multifactorial), with the developmental story handed off to the other teams.
What a finished product looks like
This is a model of the work you should turn in. Use it to check your own: match the structure and the level of detail, do not copy it. Your wording should be your own.
Developmental team entry: Between weeks 4 and 12, the left lip-front fusion (~week 6) and the secondary palate fusion (~weeks 8 to 12) failed to complete, so the failed step is lip and palate fusion within that window. Two pieces of evidence that the failure is isolated rather than syndromic: the newborn exam found no other birth defects, and the cranial neural crest built a normal jaw, ears, and face apart from the cleft, so no broad patterning program collapsed. The cleft is multifactorial, meaning several small genetic, epigenetic, and environmental contributions added up over a threshold rather than one all-or-nothing gene, which fits the sparse family history and the second-hit behavior of isolated clefting (PMID:26589921; PMID:28550290). We find an isolated, multifactorial fusion failure, and we pass Mateo to the genetics, anatomical, and clinical teams to add their views.
How this was built, step by step
The finished product above did not appear all at once. Here is the path from the question to the turned-in work, so you can follow the same steps.
- 1Start from today's question: Assembling everything we learned, what is the complete of Mateo's , and what kind of cleft is it?
- 2Work the Model and the Explore questions to reason it out before writing anything.
- 3Pull the specific evidence the product needs from the reading and any database you used.
- 4Write it up in the required format: Write the developmental team's one-paragraph entry for Mateo's . It must (1) name the failed step and its window, (2) give two pieces of evidence that the failure is isolated rather than syndromic, (3) state that it is multifactorial and say what that means, and (4) end by handing the case to the next teams. Keep it honest and free of overpromising; Mateo is a composite case.
- 5Check it against the rubric, then submit.
| Criterion | Proficient | Developing | Beginning |
|---|---|---|---|
| Complete | Every required part of the artifact is present and filled in. | Most parts are present, but one is missing or left blank. | Several parts are missing. |
| Accurate | The science and data are correct and match the evidence. | Mostly correct, with a small factual slip. | Key science or data is wrong. |
| Scientific reasoning (CER) | States a claim, backs it with specific evidence, and explains the reasoning. | Has a claim and evidence, but the reasoning is thin or missing. | Gives an answer with no evidence or reasoning. |
| Professional communication | Clear, organized, and labeled the way a clinician or scientist would write it. | Readable but disorganized or missing labels. | Hard to follow. |
| Submitted | Turned in the right way (Schoology for routine work) and confirmed. | Turned in, but in the wrong place or unconfirmed. | Not turned in. |
- CompleteProficient: Nothing is left blank: the model fills every part of "Write the developmental team's one-paragraph entry for Mateo's Domain Report. It must (1) name the failed step and its window, (2) give two pieces of evidence that the failure is isolated rather than syndromic, (3) state that it is multifactorial and say what that means, and (4) end by handing the case to the next teams. Keep it honest and free of overpromising; Mateo is a composite case.".
- AccurateProficient: Every number and claim matches the case evidence.
- Scientific reasoning (CER)Proficient: It names a claim, cites the specific evidence, and explains the reasoning, not just the answer.
- Professional communicationProficient: It is organized and labeled like a real chart note.
- SubmittedProficient: It would be turned in on Schoology and confirmed.
WebXam problem for today's skill
One exam-style question that uses exactly what you practiced today. Try it before you reveal the answer, then read why each choice is right or wrong.
Tap an answer to see the full explanation. Nothing is recorded or graded.