SNP and PTC case
Connect a single-nucleotide polymorphism to a phenotype using the PTC-tasting genotype dataset.
Genotype-to-phenotype table for three individuals (homozygous/heterozygous labeled) and a written carrier prediction.
- 1Do thisConnect a single-nucleotide polymorphism to a phenotype using the PTC-tasting genotype dataset.
- 2Use this resource
- 3Submit thisData table: Genotype-to-phenotype table for three individuals (homozygous/heterozygous labeled) and a written carrier prediction.
- 4Submit it here
- 1CMSD website. Go to clevelandmetroschools.org and click the Clever button.
- 2Clever. Clever opens. Sign in if it asks.
- 3Microsoft (district) login. Use your district Microsoft account (the one for school).
- 4Schoology. Open Schoology, then your class, then Assignments, and find the file named below.
The file to submit is named: Genetics of Disease (Medical Interventions) › Inheritance review, pedigree logic, SNPs, genetic counseling, and the MP1 data inflection. › Data tableOpen Schoology
- CER:
- Claim, Evidence, Reasoning — make a claim, back it with evidence, explain your reasoning.
- SOP:
- Standard Operating Procedure — the exact steps to follow (especially in a lab).
- Tracker:
- Your PLTW progress log where you record completed evidence.
- myPLTW:
- The PLTW course site where you do the online activities — you open it through Schoology.
Minute-by-minute · 80-minute block
💡 Big idea: How does a single DNA letter change determine whether you taste bitterness or not?
- 0-8Hook: PTC tasting demo or description; introduce SNP vocabulary
- 8-25Open dataset; locate SNP column; record genotype and phenotype for three individuals
- 25-40Mark each as homozygous or heterozygous; decide if tasting allele tracks phenotype
- 40-55Write one evidence sentence; predict carrier status for one labeled person
- 55-70Partner check: verify allele language and carrier logic
- 70-80Submit table and prediction to course shell
- • Hook: Pass around PTC strips (if available) or describe the tasting phenotype; ask who tasted bitterness.
- • Why it matters: This same SNP-to-phenotype logic underlies pharmacogenomics, where one DNA letter determines drug response.
- • Today's work: You read a real genotype dataset and connect alleles to phenotypes the same way a lab does.
- • Exit goal: Genotype-to-phenotype table and carrier prediction submitted before the bell.
- 1Open the teacher genotype dataset in the shell and find the SNP column for the PTC-tasting gene.
- 2For three people, write their genotype next to their phenotype and mark homozygous or heterozygous.
- 3Decide whether the tasting allele tracks with the trait and write one sentence of evidence.
- 4Predict the carrier status of one labeled person using allele language.
- 5Submit your genotype-to-phenotype table and prediction as your daily evidence.
- • You'll be able to read a SNP genotype and pair it to a phenotype.
- • You'll be able to predict carrier status from genotype data.
- • A SNP is a single base-pair variation at a specific locus; millions exist across the human genome.
- • The TAS2R38 gene has a common SNP that distinguishes tasters from non-tasters of phenylthiocarbamide (PTC).
- • Homozygous dominant and heterozygous individuals express the taster phenotype; homozygous recessive individuals do not.
Your PLTW work today
Inheritance review, pedigree logic, SNPs, genetic counseling, and the MP1 data inflection. · SNP and PTC case
Day 3 of this lesson. Open this exact section in myPLTW (reached through Schoology), then do the work below.
Do this: Open Activity 2.1.3 Test Your Own Genes in myPLTW and use the teacher genotype dataset to connect SNP alleles to phenotypes.
Mark the SNP activity complete after your genotype-to-phenotype table and carrier prediction are submitted.
Pedigree should be done (Tuesday); SNP table and carrier prediction due today.
Genotype-to-phenotype table with homozygous/heterozygous labels and carrier prediction submitted.
All PLTW activities are completed inside the PLTW course environment — this page only gives direction. Submit producibles on Schoology.
Today's PLTW tracker
Check things off as you work, then submit. This tells Mr. Mendoza how you're doing so he can help the class. It does not replace turning in your producible on Schoology.
Use the code Mr. Mendoza gave you, not your name. Saved on this device.
Inheritance review, pedigree logic, SNPs, genetic counseling, and the MP1 data inflection. · SNP and PTC case
Open Activity 2.1.3 Test Your Own Genes in myPLTW and use the teacher genotype dataset to connect SNP alleles to phenotypes.
Pedigree should be done (Tuesday); SNP table and carrier prediction due today.
This is how Mr. Mendoza sees the class keeping pace with PLTW. Be honest, it only helps if it is accurate.
🎯 Connect a single-nucleotide polymorphism to a phenotype using the PTC-tasting genotype dataset.
- Open the teacher genotype dataset in the shell and find the SNP column for the PTC-tasting gene.
- For three people, write their genotype next to their phenotype and mark homozygous or heterozygous.
- Decide whether the tasting allele tracks with the trait and write one sentence of evidence.
- Predict the carrier status of one labeled person using allele language.
- Submit your genotype-to-phenotype table and prediction as your daily evidence.
Data table: Genotype-to-phenotype table for three individuals (homozygous/heterozygous labeled) and a written carrier prediction.
Submit on SchoologyUpload by 11:29 PM for full credit.
| Task | Who |
|---|---|
| Open the teacher genotype dataset in the shell and find the SNP column for the PTC-tasting gene. | _______ |
| For three people, write their genotype next to their phenotype and mark homozygous or heterozygous. | _______ |
| Decide whether the tasting allele tracks with the trait and write one sentence of evidence. | _______ |
| Predict the carrier status of one labeled person using allele language. | _______ |
| Submit your genotype-to-phenotype table and prediction as your daily evidence. | _______ |
Working solo? Put your own name in "Who" for every row.
- You'll be able to read a SNP genotype and pair it to a phenotype.
- You'll be able to predict carrier status from genotype data.
Teacher-posted resources
Classroom documents for this lesson. Ones marked “Open the file” open right here; the rest are posted in Schoology. Use the label on each card to choose the right move.
Use this after the required lesson work when you are ready for a harder application or a deeper connection.
Placement rationale
Matched Genetic testing, PTC, pedigree, SNPs by path:Medical-Interventions/Unit-2_How-to-Screen-Your-Genes/2.1_Genetic-Testing-and-Screening; keywords:genetic testing, screening, ptc. Score 150. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).
Use this as the classroom resource for Genetic testing, PTC, pedigree, SNPs.
Placement rationale
Matched Genetic testing, PTC, pedigree, SNPs by path:Medical-Interventions/Unit-2_How-to-Screen-Your-Genes/2.1_Genetic-Testing-and-Screening; keywords:genetic testing, screening, snp. Score 146. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).
Use this if you were absent, got stuck, or need another pass before you submit the lesson artifact.
Placement rationale
Matched Genetic testing, PTC, pedigree, SNPs by path:Medical-Interventions/Unit-2_How-to-Screen-Your-Genes/2.1_Genetic-Testing-and-Screening; keywords:genetic testing, screening. Score 142. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).
How to get there: open the CMSD website, click Clever, sign in with your Microsoft (district) account, then open Schoology from Clever.
This unit's vocabulary
Tap the speaker to hear a term. Weekly vocabulary task: add two of these terms to your notebook glossary with a definition and an example in your own words.
WebXam practice
Cumulative WebXam review
A quick mixed-review pulling questions from earlier units plus today, so the WebXam material stays fresh.
Where this leads — careers
What today's skills lead to. These are real health-science careers this course builds toward. Tap one to see, on the US Department of Labor's O*NET site, what the job actually involves, what it pays, and how fast it is growing.
What to do if you were absent
From home, use the provided teacher genotype dataset to complete the same case: build the genotype-to-phenotype table for three people and predict one person's carrier status with a written explanation.
Teacher genotype dataset (PLTW course shell)Then submit your Data table on Schoology.
Class still runs. Complete the online activity above (it's self-guided). Need the concept taught without a teacher? Use this authoritative explainer:
MedlinePlus: What is genetic testing?Optional extra credit (async)
You've passed Unit 2, so the optional extra-credit track is open. Complete reserved-unit work from home (virtual labs included) for extra credit, all submitted on Schoology.
Open the extra-credit track- CompleteEvery required part of the artifact is present, nothing left blank.
- AccurateThe science and the data are correct and match the evidence.
- Scientific reasoningYou explain your claim with evidence and reasoning (CER), not just an answer.
- Professional communicationClear, organized, labeled, and written the way a clinician or scientist would.
- SubmittedTurned in the right way (Schoology for routine work) and confirmed.
Drop your Fri, Mar 12, 2027 · SNP and PTC case here. Use a clear file name (your initials + project). Routine work still goes to Schoology (via the CMSD portal).
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