Fri, Apr 9, 2027Spring (Semester 2) · Week 12Day 51 of 6780-min block

Gene therapy ethics CER

Today's target

Submit a complete gene therapy ethics CER weighing benefit against off-target and heritability risks.

Due today · CER Required

Complete gene therapy ethics CER: claim on whether the case patient should receive therapy, two evidences from vector chart and CRISPR work, reasoning naming one risk.

Your 4 steps today
  1. 1
    Do this
    Submit a complete gene therapy ethics CER weighing benefit against off-target and heritability risks.
  2. 2
  3. 3
    Submit this
    CER: Complete gene therapy ethics CER: claim on whether the case patient should receive therapy, two evidences from vector chart and CRISPR work, reasoning naming one risk.
  4. 4
    Submit it here
    1. 1CMSD website. Go to clevelandmetroschools.org and click the Clever button.
    2. 2Clever. Clever opens. Sign in if it asks.
    3. 3Microsoft (district) login. Use your district Microsoft account (the one for school).
    4. 4Schoology. Open Schoology, then your class, then Assignments, and find the file named below.
    The file to submit is named: Genetics of Disease (Medical Interventions) › Gene therapy, viral vectors, somatic vs. germline editing, CRISPR basics, reproductive screening. › CER
    Open Schoology
Were you absent? Jump to the make-up plan
Where this fits
Tested on (Ohio WebXam)
Genetics of Disease · 072130
PLTW lesson
MI · Gene therapy ethics CER
WebXam domain
Bio-Molecular Technology
Evidence to produce
CER
Quick glossary
CER:
Claim, Evidence, Reasoning — make a claim, back it with evidence, explain your reasoning.
SOP:
Standard Operating Procedure — the exact steps to follow (especially in a lab).
Tracker:
Your PLTW progress log where you record completed evidence.
myPLTW:
The PLTW course site where you do the online activities — you open it through Schoology.
Learn first

Minute-by-minute · 80-minute block

💡 Big idea: How do you write a defensible recommendation when the technology that could help also carries risks we cannot fully predict?

  1. 0-15Assemble evidence: pull two strongest points from vector chart and CRISPR annotation
  2. 15-50Write final ethics CER: claim on patient recommendation, two evidences, reasoning naming one risk
  3. 50-65Peer review: verify reasoning names a specific risk (off-target or heritability)
  4. 65-75Revise based on peer note; finalize
  5. 75-78Submit gene therapy ethics CER
  6. 78-80Teacher confirms unit complete; preview unit2-synthesis
Mr. Mendoza's 5-minute intro
  • Hook: Return to the germline debate claim from Monday and ask: does your CRISPR annotation change your position?
  • Why it matters: Clinicians and ethicists write exactly this kind of benefit-vs.-risk CER when advising policy.
  • Today's structure: 15 min evidence assembly, 35 min CER writing, 20 min peer review and revision, 10 min final submit.
  • Exit goal: Complete gene therapy ethics CER submitted before the bell.
Do this, step by step
  1. 1Combine your vector chart and CRISPR notes into the evidence for one CER.
  2. 2Write your final claim on whether the case patient should receive the gene therapy.
  3. 3Support it with two pieces of evidence and reasoning that names one risk.
  4. 4Submit your gene therapy ethics CER for the week-end summative.
You'll be able to
  • You'll be able to write a complete, evidence-based gene therapy CER.
  • You'll be able to weigh benefit against off-target and heritability risk.
Know by the end
  • A strong ethics CER names the benefit, the risk, and the reasoning that tips the balance one way.
  • Off-target edits and heritability (for germline therapies) are the two primary risk categories in gene therapy ethics.
  • This synthesis connects Molecular and Genetic Technology and Biotech Research domains of WebXam 072130.
Do the work

Your PLTW work today

Open this PLTW section today

Gene therapy, viral vectors, somatic vs. germline editing, CRISPR basics, reproductive screening. · Gene therapy ethics CER

Day 4 of this lesson. Open this exact section in myPLTW (reached through Schoology), then do the work below.

Do this: Open the gene-therapy unit summative in myPLTW and confirm all Activities 2.2.1 and 2.2.2 are marked complete before submitting your ethics CER.

Complete

Mark the gene therapy ethics CER activity complete after submission.

How far to get

CRISPR annotation and CER should be done (Thursday); gene-therapy unit at 100% today.

Upload as evidence

Screenshot of completed gene-therapy unit progress page as your summative artifact.

All PLTW activities are completed inside the PLTW course environment — this page only gives direction. Submit producibles on Schoology.

The plan

Today's PLTW tracker

Check things off as you work, then submit. This tells Mr. Mendoza how you're doing so he can help the class. It does not replace turning in your producible on Schoology.

Use the code Mr. Mendoza gave you, not your name. Saved on this device.

Gene therapy, viral vectors, somatic vs. germline editing, CRISPR basics, reproductive screening.Day 4 of this projectSee the full week plan
Today's PLTW target

Gene therapy, viral vectors, somatic vs. germline editing, CRISPR basics, reproductive screening. · Gene therapy ethics CER

Open the gene-therapy unit summative in myPLTW and confirm all Activities 2.2.1 and 2.2.2 are marked complete before submitting your ethics CER.

CRISPR annotation and CER should be done (Thursday); gene-therapy unit at 100% today.

This is how Mr. Mendoza sees the class keeping pace with PLTW. Be honest, it only helps if it is accurate.

1 · What you do today

🎯 Submit a complete gene therapy ethics CER weighing benefit against off-target and heritability risks.

  • Combine your vector chart and CRISPR notes into the evidence for one CER.
  • Write your final claim on whether the case patient should receive the gene therapy.
  • Support it with two pieces of evidence and reasoning that names one risk.
  • Submit your gene therapy ethics CER for the week-end summative.
2 · Turn in today

CER: Complete gene therapy ethics CER: claim on whether the case patient should receive therapy, two evidences from vector chart and CRISPR work, reasoning naming one risk.

Submit on Schoology

Upload by 11:29 PM for full credit.

3 · Who's doing what (team)
TaskWho
Combine your vector chart and CRISPR notes into the evidence for one CER._______
Write your final claim on whether the case patient should receive the gene therapy._______
Support it with two pieces of evidence and reasoning that names one risk._______
Submit your gene therapy ethics CER for the week-end summative._______

Working solo? Put your own name in "Who" for every row.

4 · Words I can use correctly
5 · I'm successful today when I can…
  • You'll be able to write a complete, evidence-based gene therapy CER.
  • You'll be able to weigh benefit against off-target and heritability risk.
6 · Reflection & next steps
Where are you today?0/6 checked
Pick your period and code first.
Explore

Teacher-posted resources

Classroom documents for this lesson. Ones marked “Open the file” open right here; the rest are posted in Schoology. Use the label on each card to choose the right move.

Catch-up / reteachFor: Need extra support
Lesson 2.2 Our Genetic Future (preface/overview)
worksheet/handoutOpens here
Open the file

Use this if you were absent, got stuck, or need another pass before you submit the lesson artifact.

Placement rationale

Matched Gene therapy, CRISPR, reproductive ethics by path:Medical-Interventions/Unit-2_How-to-Screen-Your-Genes/2.2_Our-Genetic-Future; keywords:gene therapy, reproductive. Score 138. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).

Use during lessonFor: Everyone
Activity 2.2.2 Reproductive Technology
worksheet/handoutOpens here
Open the file

Open this when the class reaches this activity and use it to complete the required lesson artifact.

Placement rationale

Matched Gene therapy, CRISPR, reproductive ethics by path:Medical-Interventions/Unit-2_How-to-Screen-Your-Genes/2.2_Our-Genetic-Future; keywords:ethics, reproductive. Score 138. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).

Extension / challengeFor: Ready to go deeper
Gene Therapy Sickle Cell POGIL Activity
activity/labOpens here
Open the file

Use this after the required lesson work when you are ready for a harder application or a deeper connection.

Placement rationale

Matched Gene therapy, CRISPR, reproductive ethics by path:Medical-Interventions/Unit-2_How-to-Screen-Your-Genes/00_Unit-Overview; keywords:gene therapy, crispr. Score 134. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).

How to get there: open the CMSD website, click Clever, sign in with your Microsoft (district) account, then open Schoology from Clever.

Words

This unit's vocabulary

gene therapyvectorCRISPR-Cas9(CRISPR-associated protein 9 gene-editing system)somaticgermline/JURM-line/off-targetinformed consent

Tap the speaker to hear a term. Weekly vocabulary task: add two of these terms to your notebook glossary with a definition and an example in your own words.

Check yourself

WebXam practice

Tap an answer to check it · nothing is recorded or graded
Gene therapy is best defined as a type of disease treatment in which
Many vectors used to deliver healthy genes in gene therapy are viruses. Why are viruses a logical choice?
A plasmid that artificially carries foreign genetic material into another cell is called a
One major challenge that keeps gene therapy from being perfect is complete integration, which means
Check yourself

Cumulative WebXam review

A quick mixed-review pulling questions from earlier units plus today, so the WebXam material stays fresh.

Tap an answer to check it · nothing is recorded or graded
[Review: Reading the Family Tree: Genetic Testing Launch] A single nucleotide polymorphism (SNP) is best described as which of the following?
[Review: From Sample to Bands: Comparing Testing Methods] Restriction enzymes are used in genetic testing because they
[Review: Heat Maps and Hunches: Reading Gene Expression] On a microarray, a saturated YELLOW spot tells a scientist that the gene is
Gene therapy is best defined as a type of disease treatment in which
Explore

Where this leads — careers

What today's skills lead to. These are real health-science careers this course builds toward. Tap one to see, on the US Department of Labor's O*NET site, what the job actually involves, what it pays, and how fast it is growing.

Safety net

What to do if you were absent

If YOU are absent

Today is individual PLTW work, so do exactly what we did in class, from home: complete the same PLTW target above, then submit your CER.

Open Schoology (CMSD) and keep going

How to get there: open the CMSD website, click Clever, sign in with your Microsoft (district) account, then open Schoology from Clever.

If MR. MENDOZA is absent

Class still runs. Complete the online activity above (it's self-guided). Need the concept taught without a teacher? Use this authoritative explainer:

MedlinePlus: What is gene therapy?
Explore

Optional extra credit (async)

You've passed Unit 2, so the optional extra-credit track is open. Complete reserved-unit work from home (virtual labs included) for extra credit, all submitted on Schoology.

Open the extra-credit track
How this is graded
For: CER — Complete gene therapy ethics CER: claim on whether the case patient should receive therapy, two evidences from vector chart and CRISPR work, reasoning naming one risk.
  • Complete
    Every required part of the artifact is present, nothing left blank.
  • Accurate
    The science and the data are correct and match the evidence.
  • Scientific reasoning
    You explain your claim with evidence and reasoning (CER), not just an answer.
  • Professional communication
    Clear, organized, labeled, and written the way a clinician or scientist would.
  • Submitted
    Turned in the right way (Schoology for routine work) and confirmed.
Submission Zone

Drop your Fri, Apr 9, 2027 · Gene therapy ethics CER here. Use a clear file name (your initials + project). Routine work still goes to Schoology (via the CMSD portal).

Upload a project