Viral vector chart
Chart how viral vectors deliver a therapeutic gene and distinguish somatic from germline targets.
Viral vector delivery diagram with labeled components, somatic vs. germline distinction, two-vector comparison row, and one sentence on vector-cell targeting.
- 1Do thisChart how viral vectors deliver a therapeutic gene and distinguish somatic from germline targets.
- 2Use this resource
- 3Submit thisNotebook check: Viral vector delivery diagram with labeled components, somatic vs. germline distinction, two-vector comparison row, and one sentence on vector-cell targeting.
- 4Submit it here
- 1CMSD website. Go to clevelandmetroschools.org and click the Clever button.
- 2Clever. Clever opens. Sign in if it asks.
- 3Microsoft (district) login. Use your district Microsoft account (the one for school).
- 4Schoology. Open Schoology, then your class, then Assignments, and find the file named below.
The file to submit is named: Genetics of Disease (Medical Interventions) › Gene therapy, viral vectors, somatic vs. germline editing, CRISPR basics, reproductive screening. › Notebook checkOpen Schoology
- CER:
- Claim, Evidence, Reasoning — make a claim, back it with evidence, explain your reasoning.
- SOP:
- Standard Operating Procedure — the exact steps to follow (especially in a lab).
- Tracker:
- Your PLTW progress log where you record completed evidence.
- myPLTW:
- The PLTW course site where you do the online activities — you open it through Schoology.
Minute-by-minute · 80-minute block
💡 Big idea: How does a virus, reprogrammed to carry a therapeutic gene, become medicine instead of a threat?
- 0-8Hook cartoon; introduce viral vector concept and engineering rationale
- 8-25Draw vector-to-cell delivery diagram with labeled vector, payload, and target cell
- 25-40Mark edit as somatic or germline; write one-line explanation of the difference
- 40-58Add comparison row: two vector types, capacity and safety from case notes
- 58-72Write one sentence on why vector choice determines which cells are treated
- 72-80Submit vector chart to course shell; note Wednesday is no school
- • Hook: Show a cartoon of a virus delivering a package to a cell and ask: what would you change about this delivery system to make it safe?
- • Why it matters: Choosing the wrong vector has caused immune reactions and insertional mutagenesis in early gene therapy trials.
- • Today's work: You chart the delivery mechanism and compare two vectors so you can explain vector selection in the case.
- • Exit goal: Vector chart submitted before the bell.
- 1Draw a viral vector carrying a healthy gene into a target cell, labeling vector and payload.
- 2Mark whether the edit is somatic or germline and explain the difference in one line.
- 3Add a row comparing two vector types on capacity and safety from the case notes.
- 4Write one sentence on why vector choice affects which cells are treated.
- 5Submit your vector chart as your daily evidence.
- • You'll be able to diagram viral vector gene delivery.
- • You'll be able to distinguish somatic from germline edits.
- • Viral vectors are engineered to remove disease-causing genes and replace them with a therapeutic payload; they retain their ability to enter and deliver DNA to cells.
- • Adeno-associated virus (AAV) is a common vector: small payload capacity, low immune response, non-integrating; retroviruses integrate but carry higher insertion-mutation risk.
- • Somatic gene therapy targets differentiated cells (liver, lung, blood); effects are not heritable.
Your PLTW work today
Gene therapy, viral vectors, somatic vs. germline editing, CRISPR basics, reproductive screening. · Viral vector chart
Day 2 of this lesson. Open this exact section in myPLTW (reached through Schoology), then do the work below.
Do this: Open Activity 2.2.1 Gene Therapy in myPLTW and diagram how a viral vector delivers a therapeutic gene into a target cell.
Mark the viral vector activity complete after your vector chart is submitted.
Monday debate should be posted; vector chart due today.
Viral vector delivery diagram with somatic/germline distinction and two-vector comparison submitted.
All PLTW activities are completed inside the PLTW course environment — this page only gives direction. Submit producibles on Schoology.
Today's PLTW tracker
Check things off as you work, then submit. This tells Mr. Mendoza how you're doing so he can help the class. It does not replace turning in your producible on Schoology.
Use the code Mr. Mendoza gave you, not your name. Saved on this device.
Gene therapy, viral vectors, somatic vs. germline editing, CRISPR basics, reproductive screening. · Viral vector chart
Open Activity 2.2.1 Gene Therapy in myPLTW and diagram how a viral vector delivers a therapeutic gene into a target cell.
Monday debate should be posted; vector chart due today.
This is how Mr. Mendoza sees the class keeping pace with PLTW. Be honest, it only helps if it is accurate.
🎯 Chart how viral vectors deliver a therapeutic gene and distinguish somatic from germline targets.
- Draw a viral vector carrying a healthy gene into a target cell, labeling vector and payload.
- Mark whether the edit is somatic or germline and explain the difference in one line.
- Add a row comparing two vector types on capacity and safety from the case notes.
- Write one sentence on why vector choice affects which cells are treated.
- Submit your vector chart as your daily evidence.
Notebook check: Viral vector delivery diagram with labeled components, somatic vs. germline distinction, two-vector comparison row, and one sentence on vector-cell targeting.
Submit on SchoologyUpload by 11:29 PM for full credit.
| Task | Who |
|---|---|
| Draw a viral vector carrying a healthy gene into a target cell, labeling vector and payload. | _______ |
| Mark whether the edit is somatic or germline and explain the difference in one line. | _______ |
| Add a row comparing two vector types on capacity and safety from the case notes. | _______ |
| Write one sentence on why vector choice affects which cells are treated. | _______ |
| Submit your vector chart as your daily evidence. | _______ |
Working solo? Put your own name in "Who" for every row.
- You'll be able to diagram viral vector gene delivery.
- You'll be able to distinguish somatic from germline edits.
Teacher-posted resources
Classroom documents for this lesson. Ones marked “Open the file” open right here; the rest are posted in Schoology. Use the label on each card to choose the right move.
Use this if you were absent, got stuck, or need another pass before you submit the lesson artifact.
Placement rationale
Matched Gene therapy, CRISPR, reproductive ethics by path:Medical-Interventions/Unit-2_How-to-Screen-Your-Genes/2.2_Our-Genetic-Future; keywords:gene therapy, reproductive. Score 138. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).
Open this when the class reaches this activity and use it to complete the required lesson artifact.
Placement rationale
Matched Gene therapy, CRISPR, reproductive ethics by path:Medical-Interventions/Unit-2_How-to-Screen-Your-Genes/2.2_Our-Genetic-Future; keywords:ethics, reproductive. Score 138. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).
Use this after the required lesson work when you are ready for a harder application or a deeper connection.
Placement rationale
Matched Gene therapy, CRISPR, reproductive ethics by path:Medical-Interventions/Unit-2_How-to-Screen-Your-Genes/00_Unit-Overview; keywords:gene therapy, crispr. Score 134. Visibility: student-schoology (student-facing resource; link through Schoology rather than local path).
How to get there: open the CMSD website, click Clever, sign in with your Microsoft (district) account, then open Schoology from Clever.
This unit's vocabulary
Tap the speaker to hear a term. Weekly vocabulary task: add two of these terms to your notebook glossary with a definition and an example in your own words.
WebXam practice
Cumulative WebXam review
A quick mixed-review pulling questions from earlier units plus today, so the WebXam material stays fresh.
Where this leads — careers
What today's skills lead to. These are real health-science careers this course builds toward. Tap one to see, on the US Department of Labor's O*NET site, what the job actually involves, what it pays, and how fast it is growing.
What to do if you were absent
Today is individual PLTW work, so do exactly what we did in class, from home: complete the same PLTW target above, then submit your Notebook check.
Open Schoology (CMSD) and keep goingHow to get there: open the CMSD website, click Clever, sign in with your Microsoft (district) account, then open Schoology from Clever.
Class still runs. Complete the online activity above (it's self-guided). Need the concept taught without a teacher? Use this authoritative explainer:
MedlinePlus: What is gene therapy?Optional extra credit (async)
You've passed Unit 2, so the optional extra-credit track is open. Complete reserved-unit work from home (virtual labs included) for extra credit, all submitted on Schoology.
Open the extra-credit track- CompleteEvery required part of the artifact is present, nothing left blank.
- AccurateThe science and the data are correct and match the evidence.
- Scientific reasoningYou explain your claim with evidence and reasoning (CER), not just an answer.
- Professional communicationClear, organized, labeled, and written the way a clinician or scientist would.
- SubmittedTurned in the right way (Schoology for routine work) and confirmed.
Drop your Wed, Apr 7, 2027 · Viral vector chart here. Use a clear file name (your initials + project). Routine work still goes to Schoology (via the CMSD portal).
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