Principles of Biomedical Technology (Principles of Biomedical Science)
Unit 2: Unit 2.2 Decoding a DiagnosisPBS 2.2Biotechnology Research and Experiments

Model DNA to Protein

Build a protein from DNA: copy the template strand into mRNA (T to U), then read codons to name the amino acids.

Builds on (2 levels back)inferred · high confidence
  • DNA/RNA base pairing: Building mRNA means pairing each DNA base to its partner (A-U, T-A, C-G, G-C).
  • Use a codon chart: Naming the amino acid means looking up each three-base codon on a chart.

Prerequisites are inferred: pending teacher review.

Re-learn the skill with worked practice and clear examples.

Model DNA to protein in two steps: transcribe the template strand into mRNA (T to U), then translate the mRNA codon into its amino acid using the chart.

Step 1: Transcribe
Go base by base across the DNA template, writing each mRNA partner from the table: A->U, T->A, C->G, G->C.
Step 2: Group into codons
Split the mRNA into groups of three bases. Each group of three is one codon.
Step 3: Translate
Look up each codon on the chart to name its amino acid. That string of amino acids is the protein.
Practice

A DNA template strand reads TAC. Build the mRNA (pair each base, T becomes U) and use the chart to name the amino acid.

Approved
DNA base on templatemRNA base to write
AU
TA
CG
GC
mRNA codonAmino acid
AUGMethionine (Met) - start
UUUPhenylalanine (Phe)
UACTyrosine (Tyr)
GGUGlycine (Gly)
Pairing rules for copying a DNA template strand into mRNA, and a short codon chart.
  1. A.mRNA AUG = Methionine (Met)
  2. B.mRNA UUU = Phenylalanine (Phe)
  3. C.mRNA TAC = Tyrosine (Tyr)
  4. D.mRNA GGU = Glycine (Gly)
Show the worked solution ▾

Answer: A. mRNA AUG = Methionine (Met)

  1. Step 1: Pair each base: T->A, A->U, C->G using the pairing table, so DNA TAC gives mRNA AUG.
  2. Step 2: Look up the codon: The chart shows AUG codes for Methionine (Met), the start amino acid.

Why it's right: DNA template TAC pairs to mRNA AUG (T->A, A->U, C->G), and the chart shows AUG = Methionine.

Why the others miss:
  • B: UUU comes from DNA AAA, not from TAC.
  • C: mRNA uses U, not T, so the mRNA is AUG, not TAC.
  • D: GGU comes from DNA CCA, not from TAC.

Aligned to Biotechnology Research and Experiments: transcribe and translate · reading level ~grade 9

A DNA template strand reads CCA. Pair each base into mRNA, then choose the line that names the codon you built and the amino acid it calls for.

Reviewed
  1. A.mRNA CCA, which calls for proline
  2. B.mRNA UUA, which calls for leucine
  3. C.mRNA GGU, which calls for glycine
  4. D.mRNA GGT, which calls for glycine
Show the worked solution ▾

Answer: C. mRNA GGU, which calls for glycine

  1. Step 1: Pair each base: Template C pairs with G, the second C pairs with G, and template A pairs with U.
  2. Step 2: Read the codon: That gives the mRNA codon GGU.
  3. Step 3: Look it up: GGU calls for glycine.

Why it's right: Template C gives G, C gives G, and A gives U, so the mRNA codon is GGU, and GGU calls for glycine.

Why the others miss:
  • A: This copies the DNA letters instead of pairing them. CCA really does call for proline, but that is not what this template produces.
  • B: This pairs the bases wrongly. Template C gives G, not U.
  • D: RNA never uses T. The pairing is right, but the last base has to be written as U.

Aligned to Biotechnology Research and Experiments · reading level ~grade 9

Where you'd see this
  • In Unit 2.2 Decoding a Diagnosis, this skill turns class evidence into a result another person can check.
Video library
Watch: Model DNA to Protein
Protein Synthesis: Transcription and Translation (Updated)
Amoeba Sisters · 8:47
Guided notes

Fill these in as you work through the lesson.

Big idea: You can model how a cell makes protein in two steps: transcription copies the DNA template strand into mRNA (T becomes U), and translation reads the mRNA codons to name the amino acids.
Key terms: write the meaning
  • Template strand (the DNA side that is copied):  
  • Transcription (DNA -> mRNA):  
  • mRNA (the message copy of the gene):  
  • Codon (three mRNA bases = one amino acid):  
  • Translation (mRNA codons -> amino acids):  
  • Amino acid (a protein building block):  
The rule

To copy DNA into mRNA, pair A with  , T with  , C with  , and G with  . Then read the mRNA in groups of   bases to name each amino acid.

Check yourself
  1. When you build mRNA from DNA, which base replaces T? 
  2. How many mRNA bases make one codon? 
  3. What two steps take you from a DNA template strand to a finished chain of amino acids? 
Work one example

DNA template = TAC. Build the mRNA (pair each base, T->U) and then name the amino acid. (Answer: mRNA = AUG, which the chart shows is Methionine, the start.)