Principles of Biomedical Technology (Principles of Biomedical Science)
Unit 1: Unit 1.2 Master the MorguePBS 1.2Biotechnology Research and Experiments

Interpret Toxicology Evidence

Compare toxicology results to cutoffs and controls before making an evidence claim.

Builds on (2 levels back)inferred · high confidence
  • Use a reference chart: Indicators and microscope features must be compared to a known guide.
  • Structure and function: Students connect visible features to what tissues or molecules do.

Prerequisites are inferred: pending teacher review.

Re-learn the skill with worked practice and clear examples.

Compare toxicology results to cutoffs and controls before making an evidence claim.

Step 1: Learn the key
A toxicology result is interpreted by comparing the sample value to the and checking whether the worked.
SubstanceResultReference limit
Drug A4 ng/mLunder 5 = negative
Drug B18 ng/mL10 or more = positive
Controlexpectedvalid run
Toxicology result table
Step 2: Use the model
Read the figure, table, control, range, or protocol before choosing an answer.
Step 3: Name the limit
Say what the evidence can support and what it cannot prove yet.
Practice

Use the toxicology table. Which substance is below its reference limit?

Reviewed
SubstanceResultReference limit
Drug A4 ng/mLunder 5 = negative
Drug B18 ng/mL10 or more = positive
Controlexpectedvalid run
Toxicology result table
  1. A.The control row
  2. B.Drug A
  3. C.Drug B
  4. D.The table title
Show the worked solution ▾

Answer: B. Drug A

  1. Step 1: Read Drug A: Drug A is 4 ng/mL.
  2. Step 2: Compare limit: Under 5 is negative; 4 is below 5.

Why it's right: Drug A is below its listed reference limit.

Why the others miss:
  • A: The control checks validity.
  • C: Drug B is 18 with positive cutoff 10.
  • D: Title is not a substance.

Aligned to Biotechnology Research and Experiments · reading level ~grade 9

A screening result reads 0.8 mg/L and the cutoff on the report is written as 500 ng/mL. What has to happen before the result is called?

Reviewed
  1. A.Discard the sample, because two different units can never be compared
  2. B.Report it negative, because 0.8 is a smaller number than 500
  3. C.Convert to one unit: 0.8 mg/L equals 800 ng/mL, which sits above 500
  4. D.Report it positive, because milligrams are always bigger than nanograms
Show the worked solution ▾

Answer: C. Convert to one unit: 0.8 mg/L equals 800 ng/mL, which sits above 500

  1. Step 1: Put both on one scale: 1 mg/L is 1 microgram per mL, which is 1000 ng/mL.
  2. Step 2: Convert the sample: 0.8 mg/L is 0.8 times 1000, which is 800 ng/mL.
  3. Step 3: Compare: 800 ng/mL is above the 500 ng/mL cutoff.

Why it's right: 0.8 mg/L converts to 800 ng/mL, which is above the 500 ng/mL cutoff. Numbers can only be compared once they are on the same scale.

Why the others miss:
  • A: Units can always be converted, and converting is exactly what this result needs.
  • B: Comparing 0.8 with 500 compares two different scales, so the comparison is meaningless.
  • D: The right call here is positive, but not because of the unit names; it is because 800 exceeds 500.

Aligned to Biotechnology Research and Experiments · reading level ~grade 10

Where you'd see this
  • In Unit 1.2 Master the Morgue, this skill turns class evidence into a result another person can check.
Video library
Watch: Interpret Toxicology Evidence
Forensic Toxicology: Alcohol & Drugs | Chapter 13 – Criminalistics (13th)
Last Minute Lecture
Guided notes

Fill these in as you work through the lesson.

Big idea: Compare toxicology results to cutoffs and controls before making an evidence claim.
Key terms: write the meaning
  • Toxicology (testing for drugs, poisons, or chemicals):  
  • Cutoff (value used to call positive or negative):  
  • Control (known check that test worked):  
  • Positive result (target is at or above the cutoff):  
The rule

A toxicology result is interpreted by comparing the sample value to the   and checking whether the   worked.

Check yourself
  1. What is the sample value? 
  2. What is the cutoff? 
  3. Did the control behave as expected? 
Work one example

Drug B is 18 ng/mL and cutoff is 10 ng/mL. Write the result and one limitation.