Negative feedback model build
Students will build and run a physical model of blood-glucose negative feedback involving insulin and glucagon.
Feedback loop diagram showing insulin and glucagon responses for both a meal and a fasting scenario, with labeled negative-feedback arrows.
- 1Do thisStudents will build and run a physical model of blood-glucose negative feedback involving insulin and glucagon.
- 2Use this resource
- 3Submit thisNotebook check: Feedback loop diagram showing insulin and glucagon responses for both a meal and a fasting scenario, with labeled negative-feedback arrows.
- 4Submit it here
- 1CMSD website. Go to clevelandmetroschools.org and click the Clever button.
- 2Clever. Clever opens. Sign in if it asks.
- 3Microsoft (district) login. Use your district Microsoft account (the one for school).
- 4Schoology. Open Schoology, then your class, then Assignments, and find the file named below.
The file to submit is named: Human Anatomy & Physiology (Human Body Systems) › Unit 2.2 Everything Endocrine: Endocrine glands, hormones, feedback loops, blood sugar/insulin model. › Notebook checkOpen Schoology
- CER:
- Claim, Evidence, Reasoning — make a claim, back it with evidence, explain your reasoning.
- SOP:
- Standard Operating Procedure — the exact steps to follow (especially in a lab).
- Tracker:
- Your PLTW progress log where you record completed evidence.
- myPLTW:
- The PLTW course site where you do the online activities — you open it through Schoology.
Minute-by-minute · 80-minute block
💡 Big idea: Negative feedback loops are the core mechanism by which the body detects deviation from a set point and corrects it.
- 0-10Review: how does the pancreas detect blood-glucose change?
- 10-25Build feedback model: assign card roles for glucose, insulin, glucagon, and pancreas sensor
- 25-42Meal simulation: add glucose tokens and trace insulin response to set point
- 42-58Fasting simulation: remove glucose tokens and trace glucagon response
- 58-70Record loop diagram with labeled arrows showing negative feedback
- 70-80Pair-share and submit loop diagram
- • Every time you eat, your pancreas launches a hormone cascade to keep your blood sugar in a safe range.
- • Today you will build that cascade with cards or tokens so you can see the loop in action.
- • Modeling is a core scientific practice and a skill tested in the Evaluate Body Systems WebXam domain.
- • You will run two scenarios: eating a meal and fasting, recording what happens each time.
- 1Review how the pancreas senses high and low blood glucose.
- 2Build a feedback loop model using cards or tokens for glucose, insulin, and glucagon.
- 3Simulate a meal by adding glucose and trace the insulin response.
- 4Simulate fasting and trace the glucagon response.
- 5Record how the model returns glucose toward the set point.
- • Model correctly shows insulin lowering and glucagon raising glucose.
- • Notes describe return to set point as negative feedback.
- • Insulin is released when blood glucose rises; glucagon is released when it falls.
- • Negative feedback opposes the change that triggered the response, returning the variable toward its set point.
- • Diabetes results from disruption of this feedback loop, linking pathophysiology to homeostasis concepts on the WebXam.
Your PLTW work today
Unit 2.2 Everything Endocrine: Endocrine glands, hormones, feedback loops, blood sugar/insulin model. · Negative feedback model build
Day 3 of this lesson. Open this exact section in myPLTW (reached through Schoology), then do the work below.
Do this: Complete any reflection or check-in linked to the feedback-model activity in Lesson 2.2 Everything Endocrine on myPLTW; finish it after running both the meal and fasting simulations.
Mark the activity complete in myPLTW after submitting your labeled negative-feedback loop diagram.
Gland-and-hormone task is done; today the feedback-model task should show complete.
Note or screenshot of completion status for your tracker.
All PLTW activities are completed inside the PLTW course environment — this page only gives direction. Submit producibles on Schoology.
Today's PLTW tracker
Check things off as you work, then submit. This tells Mr. Mendoza how you're doing so he can help the class. It does not replace turning in your producible on Schoology.
Use the code Mr. Mendoza gave you, not your name. Saved on this device.
Unit 2.2 Everything Endocrine: Endocrine glands, hormones, feedback loops, blood sugar/insulin model. · Negative feedback model build
Complete any reflection or check-in linked to the feedback-model activity in Lesson 2.2 Everything Endocrine on myPLTW; finish it after running both the meal and fasting simulations.
Gland-and-hormone task is done; today the feedback-model task should show complete.
This is how Mr. Mendoza sees the class keeping pace with PLTW. Be honest, it only helps if it is accurate.
🎯 Students will build and run a physical model of blood-glucose negative feedback involving insulin and glucagon.
- Review how the pancreas senses high and low blood glucose.
- Build a feedback loop model using cards or tokens for glucose, insulin, and glucagon.
- Simulate a meal by adding glucose and trace the insulin response.
- Simulate fasting and trace the glucagon response.
- Record how the model returns glucose toward the set point.
Notebook check: Feedback loop diagram showing insulin and glucagon responses for both a meal and a fasting scenario, with labeled negative-feedback arrows.
Submit on SchoologyUpload by 11:29 PM for full credit.
| Task | Who |
|---|---|
| Review how the pancreas senses high and low blood glucose. | _______ |
| Build a feedback loop model using cards or tokens for glucose, insulin, and glucagon. | _______ |
| Simulate a meal by adding glucose and trace the insulin response. | _______ |
| Simulate fasting and trace the glucagon response. | _______ |
| Record how the model returns glucose toward the set point. | _______ |
Working solo? Put your own name in "Who" for every row.
- Model correctly shows insulin lowering and glucagon raising glucose.
- Notes describe return to set point as negative feedback.
Resources & readings
Vetted readings and references for this unit. Use them to prepare, to catch up if you were absent, or to go deeper on today's target.
Lab & supplies
WebXam practice
Cumulative WebXam review
A quick mixed-review pulling questions from earlier units plus today, so the WebXam material stays fresh.
Where this leads — careers
What today's skills lead to. These are real health-science careers this course builds toward. Tap one to see, on the US Department of Labor's O*NET site, what the job actually involves, what it pays, and how fast it is growing.
What to do if you were absent
Run your glucose feedback model through one meal and one fasting cycle, recording hormone responses at each step.
MedlinePlus: Blood SugarThen submit your Notebook check on Schoology.
Class still runs. Complete the online activity above (it's self-guided). Need the concept taught without a teacher? Use this authoritative explainer:
MedlinePlus: Endocrine DiseasesOptional extra credit (async)
You've passed Unit 2, so the optional extra-credit track is open. Complete reserved-unit work from home (virtual labs included) for extra credit, all submitted on Schoology.
Open the extra-credit track- CompleteEvery required part of the artifact is present, nothing left blank.
- AccurateThe science and the data are correct and match the evidence.
- Scientific reasoningYou explain your claim with evidence and reasoning (CER), not just an answer.
- Professional communicationClear, organized, labeled, and written the way a clinician or scientist would.
- SubmittedTurned in the right way (Schoology for routine work) and confirmed.
Drop your Fri, Oct 23, 2026 · Negative feedback model build here. Use a clear file name (your initials + project). Routine work still goes to Schoology (via the CMSD portal).
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